Effects of dietary restriction on physical performance in mice
Effects of dietary restriction on physical performance in mice
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DOI：
10.2114/jpa.24.209
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发表时间：
2005-05-01
期刊：
影响因子：
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通讯作者：
Sonoda, Yoshiaki
中科院分区：
文献类型：
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作者：
Ishihara, Hiroyasu;Fan WenYing;Sonoda, Yoshiaki
众所周知，饮食限制可以延长实验室动物的寿命。然而，人们对饮食限制对身体表现的影响知之甚少。为了评估身体性能，我们每周测量四个项目指标：爬出障碍物的时间，摆脱胶带束缚的时间，挂在横杆上的时间和防滑能力。ICR小鼠的饮食从7周龄到24周龄受到限制。在第7至9周龄期间，饮食限制小鼠的体重下降。第10周后，体重恢复。在对分配的任务的反应中，饮食限制的小鼠在所有活动中表现更好：它们更快地爬出障碍物，更快地从胶带束缚中解脱出来，挂在酒吧里的时间更长，更好地抵抗滑下斜坡。这些结果表明，限制饮食的小鼠比自由进食的小鼠具有上级体能，例如克服或避免生命危险所需的体能。
Dietary restriction is known to prolong life in laboratory animals. However, little is known about the effects of dietary restriction on physical performance. To evaluate physical performance, we measured four item indices: time to climb out of obstacles, time to escape restraint by gummed tape, time hanging from a bar, and ability to resist slipping every week. The diets of ICR mice were restricted from the age of 7 weeks through 24 weeks. Body weight of the diet-restricted mice decreased during the 7th to 9th weeks of age. After the 10th week, weight gain resumed. In response to assigned tasks, the diet-restricted mice performed better in all activities: they climbed out of obstacles faster, freed themselves sooner from restraint by gummed tape, hung from a bar longer, and better resisted slipping down a slope. These results suggest that diet-restricted mice have superior physical abilities, such as those required to overcome or avoid risks to life, than do ad-libitum-fed mice.