Obstructive Sleep Apnea and Increased Risk of Glaucoma A Population-Based Matched-Cohort Study
Obstructive Sleep Apnea and Increased Risk of Glaucoma A Population-Based Matched-Cohort Study
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DOI：
10.1016/j.ophtha.2013.01.006
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发表时间：
2013-08-01
期刊：
影响因子：
13.7
通讯作者：
Lin, Herng-Ching
中科院分区：
文献类型：
--
作者：
Lin, Ching-Chun;Hu, Chao-Chien;Lin, Herng-Ching
目的：以前的研究报道了阻塞性睡眠呼吸暂停（OSA）患者青光眼的患病率增加。然而，OSA患者中开角型青光眼（OAG）的风险仍不清楚。使用一个全国性的，以人口为基础的数据集在台湾，这项研究的目的是检查的患病率和风险的OSA患者在5年的随访期后，诊断为OSA.Design：一个回顾性的，匹配的队列study.Participants和控制：这项研究使用的数据来源于纵向健康保险数据库2000年。我们包括1012例OSA的研究队列和随机选择的6072名受试者在comparationgroup.Methods：在这项研究中的每一个主题是单独跟踪了5年的时间，以确定这些受试者谁随后收到的诊断OAG。采用考克斯比例风险回归分析计算研究组和对照组之间OAG的5年风险。主要结果指标：研究组和对照组之间OAG的发生率和风险。在5年随访期间，每1000人年的发病率为11.26（95%置信区间[CI]，8.61-14.49）和6.76（95% CI，5.80-7.83）。在对随访期间的月收入、地理区域、糖尿病、高血压、冠心病、肥胖、高脂血症、肾脏疾病、甲状腺功能减退和眼科门诊就诊次数进行校正后，分层考克斯比例风险回归显示，OSA受试者5年内OAG的风险比为1.67（95%CI，1.30-2.17; P
Purpose: Previous studies had reported an increased prevalence of glaucoma in patients with obstructive sleep apnea (OSA). However, the risk of open-angle glaucoma (OAG) among patients with OSA remains unclear. Using a nationwide, population-based dataset in Taiwan, this study aimed to examine the prevalence and risk of OAG among patients with OSA during a 5-year follow-up period after a diagnosis of OSA.Design: A retrospective, matched-cohort study.Participants and Controls: This study used data sourced from the Longitudinal Health Insurance Database 2000. We included 1012 subjects with OSA in the study cohort and randomly selected 6072 subjects in the comparison group.Methods: Each subject in this study was individually traced for a 5-year period to identify those subjects who subsequently received a diagnosis of OAG. Cox proportional hazards regression was performed to calculate the 5-year risk of OAG between the study and comparison cohorts.Main Outcome Measures: The incidence and risk of OAG between the study and comparison groups.Results: During the 5-year follow-up period, the incidence rate per 1000 person-years was 11.26 (95% confidence interval [CI], 8.61-14.49) and 6.76 (95% CI, 5.80-7.83) for subjects with and without OSA, respectively. After adjusting for monthly income, geographic region, diabetes, hypertension, coronary heart disease, obesity, hyperlipidemia, renal disease, hypothyroidism, and the number of outpatient visits for ophthalmologic care during the follow-up period, stratified Cox proportional hazards regression revealed that the hazard ratio for OAG within the 5-year period for subjects with OSA was 1.67 (95% CI, 1.30-2.17; P