Low selenium diet increases the dopamine turnover in prefrontal cortex of the rat
Low selenium diet increases the dopamine turnover in prefrontal cortex of the rat
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DOI：
10.1016/s0197-0186(96)00123-4
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发表时间：
1997-06-01
影响因子：
4.2
通讯作者：
Machado, A
中科院分区：
文献类型：
--
作者：
Castano, A;Ayala, A;Machado, A
研究表明，儿茶酚胺和吲哚胺与自由基的相互作用可能导致内源性神经毒素的形成。为了更好地了解参与神经退行性疾病的机制，显示氧化应激的证据，我们研究了基础浓度和周转率的多巴胺，去甲肾上腺素，5-羟色胺和它们的代谢产物在大鼠的前额叶皮层喂养控制或低硒饮食。与实验对照组相比，硒营养缺乏通过降低谷胱甘肽过氧化物酶活性降低了实验条件下脑的抗氧化保护作用，多巴胺和5-羟色胺周转率增加，去甲肾上腺素和5-羟基-3-吲哚乙酸周转率降低。实验大鼠多巴胺周转率的增加伴随着酪氨酸羟化酶活性的增加。这些结果表明，脑对氧化损伤的保护作用的降低可通过干扰某些单胺的更新速率而引起脑损伤。(C)1997 Elsevier Science Ltd.
It has been proposed that interaction of catecholamines and indoleamines with free radicals may result in the formation of endogenous neurotoxins. In order to better understand the mechanisms involved in neurodegenerative disorders showing evidence of oxidative stress, we have studied the basal concentrations and the turnover rates of dopamine, noradrenaline, serotonin and their metabolites in the prefrontal cortex of rats that were fed on control or low selenium diets. Nutritional deficit of selenium decreases the brain antioxidant protection in experimental conditions by the decrease in glutathione peroxidase activity.The dopamine and serotonin turnover increased and noradrenaline and 5-hydroxy-3-indoleacetic acid turnover decreased compared to experimental control animals. The increase of dopamine turnover in experimental rats was accompanied by an increase in tyrosine hydroxylase activity. These results suggest that the decrease of brain protection against oxidative damage could induce brain damage by disturbing the turnover rate of some monoamines. (C) 1997 Elsevier Science Ltd.