Complete remission in 4 patients with human herpesvirus 8-associated multicentric Castleman disease using rituximab and liposomal doxorubicin, a novel chemotherapy combination.
Complete remission in 4 patients with human herpesvirus 8-associated multicentric Castleman disease using rituximab and liposomal doxorubicin, a novel chemotherapy combination.
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使用利妥昔单抗和脂质体阿霉素（一种新型化疗组合）使 4 名人类疱疹病毒 8 相关多中心 Castleman 病患者完全缓解。
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
M. Cusnir
中科院分区：
文献类型：
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作者：
D. Peker;A. E. Martinez;M. Schwartz;M. Cusnir
质母细胞型多中心Castleman病（PMCD）是一种罕见的侵袭性淋巴细胞增生性疾病，由Frizzera及其同事于1983年首次发现。已有研究表明PMCD与卡波西肉瘤有关，并且大多数患有这两种疾病的患者都感染了人类疱疹病毒8 (HHV8)，也称为卡波西肉瘤相关疱疹病毒。2-4诊断基于临床、病理和实验室结果。常见的临床过程以反复发热、全身淋巴结病、疲劳、脾肿大、肝肿大和贫血为特征。受累淋巴结或脾脏的病理检查经常显示滤泡数量增加，其中一些有萎缩、透明化的生发中心，血管增多，滤泡间区有浆细胞片。通过HHV-8免疫组织化学染色（IHC），可以识别出从分散的滤泡周围细胞到显性淋巴瘤的各种数量的所谓的浆母细胞。我们最近的研究表明，在这些病例中，相当大比例的细胞同时感染了eb病毒（EBV）共存的卡波西肉瘤常出现在PMCD累及的淋巴结或其他部位。最初的疾病可以是自限性的；然而，预后通常很差，大多数患者在几个月内死于活动性PMCD或进展为hhv -8相关的非霍奇金淋巴瘤（NHL）
Plasmablastic-type multicentric Castleman disease (PMCD) is a rare, aggressive lymphoproliferative disorder first described by Frizzera and colleagues in 1983.1 Today, the disease is most commonly diagnosed in individuals infected with human immunodeficiency virus (HIV) type 1. It has been shown that PMCD is associated with Kaposi sarcoma, and a majority of patients with both conditions are infected by human herpesvirus 8 (HHV8), also known as Kaposi sarcoma–associated herpesvirus.2-4 The diagnosis is based on clinical, pathologic, and laboratory findings. The common clinical course is characterized by recurrent attacks of fever, generalized lymphadenopathy, fatigue, splenomegaly, hepatomegaly, and anemia. The pathologic examination of involved lymph nodes or spleen frequently shows an increased number of follicles, some of which have atrophic, hyalinized germinal centers, increased vascularity, and sheets of plasma cells within the interfollicular areas. A variable number of so-called plasmablasts, from scattered perifollicular cells to overt lymphoma, can be identified by immunohistochemical staining (IHC) with HHV-8. We have recently showed that in a significant proportion of these cases, the same cells are coinfected with Epstein-Barr virus (EBV).5 Coexistent Kaposi sarcoma is often present in lymph nodes involved by PMCD or elsewhere. The initial disease can be self-limited; however, the prognosis is usually poor and most patients die with active PMCD or progress to HHV-8–associated non-Hodgkin lymphoma (NHL) within months.6
影响因子：
20.3
作者：
Casper, C;Nichols, WG;Wald, A
通讯作者：
Wald, A