Lipid microdomains in cell surface membranes
Lipid microdomains in cell surface membranes
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DOI：
10.1016/s0959-440x(97)80117-0
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发表时间：
1997-08-01
影响因子：
6.8
通讯作者：
Edidin, M
中科院分区：
文献类型：
--
作者：
Edidin, M
通过各种实验技术检测细胞膜中的脂质微域，每一种技术都在不同的时间和空间尺度上表征微域。总而言之，脂质微区的数据尚未整合到细胞膜结构的单一模型中。事实上，过去一年的一个亮点是对实验结果的新分析，它产生了一个不需要包含任何微域的细胞膜模型。其他亮点包括对膜微域中磷脂分子数量的估计，以及对细胞膜中域形成的实时检测。在显示细胞膜内的脂质微域方面也取得了一些进展。然而，我们仍在等待一种整合了所有实验结果的新的膜结构模型。
Lipid microdomains within cell membranes are detected by a variety of experimental techniques, each of which characterizes microdomains on a different time and spatial scale. The sum of the data an lipid microdomains has yet to be integrated into a single model of cell membrane structure. Indeed, one highlight of the past year is a new analysis of experimental results which yields a model of a cell membrane which need not contain any microdomains. Other highlights are an estimate of the number of phospholipid molecules in a membrane microdomain and the detection of domain formation in cell membranes in real time. Some progress has also been made in visualizing lipid microdomains within cell membranes. We still await, however, a new model of membrane structure that integrates all experimental results.