High-yield conversion of (R)-2-octanol from the corresponding racemate by stereoinversion using Candida rugosa
High-yield conversion of (R)-2-octanol from the corresponding racemate by stereoinversion using Candida rugosa
复制标题
DOI：
10.1007/s10529-004-6310-1
复制
发表时间：
2005-01-01
影响因子：
2.7
通讯作者：
Sun, ZH
中科院分区：
文献类型：
--
作者：
Nie, Y;Xu, Y;Sun, ZH
皱褶假丝酵母（Candida rugosa）全细胞催化（R）-2-辛醇从相应的外消旋体转化，光学纯度为97% e.e. 10 h内产率达92%。以2-辛酮为中间体，通过对映选择性氧化和不对称还原的立体转化反应得到产物。
Whole cells of Candida rugosa catalyzed the conversion of (R)-2-octanol from the corresponding racemate with the optical purity of 97% e.e. and yield of 92% in 10 h. The product was formed through a stereoinversion involving enantioselective oxidation and asymmetric reduction with 2-octanone as the intermediate.