Comparison of brain natriuretic peptide and probrain natriuretic peptide in the diagnosis of cardiogenic pulmonary edema in patients aged 65 and older
Comparison of brain natriuretic peptide and probrain natriuretic peptide in the diagnosis of cardiogenic pulmonary edema in patients aged 65 and older
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DOI：
10.1111/j.1532-5415.2005.53213.x
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发表时间：
2005-04-01
影响因子：
6.3
通讯作者：
Riou, B
中科院分区：
文献类型：
--
作者：
Ray, P;Arthaud, M;Riou, B
目的：对于老年患者来说，区分心源性肺水肿（CPE）和呼吸困难的呼吸系统原因很困难。本研究的目的是比较 B 型利钠肽 (BNP) 和氨基末端片段 BNP (proBNP) 在诊断 65 岁及以上患者 CPE 方面的有用性。设计：前瞻性研究。地点：一家拥有 2,000 个床位的城市教学医院的医疗急诊科。参与者：出现急性呼吸困难且呼吸频率为 25 次/分钟或更高、分压的 65 岁及以上患者包括氧含量为 70 mmHg 或更低，或氧饱和度为 92% 或更低。 测量：入院时盲法进行的快速 BNP 和 proBNP 检测，与专家组定义的最终诊断（CPE 或无 CPE）进行比较。 结果：包括 202 名患者（平均年龄 +/- 标准差 80 +/- 9）； 88 人 (44%) 患有 CPE。 proBNP 和 BNP 值之间存在很强的相关性（相关系数=0.91，P
OBJECTIVES: Differentiating cardiogenic pulmonary edema (CPE) from respiratory causes of dyspnea is difficult in elderly patients. The aim of this study was to compare the usefulness of B-type natriuretic peptide (BNP) and amino-terminal fragment BNP (proBNP), to diagnose CPE in patients aged 65 and older.DESIGN: Prospective study.SETTING: Medical emergency department of a 2,000-bed urban teaching hospital.PARTICIPANTS: Patients aged 65 and older presenting with acute dyspnea and a respiratory rate of 25 breaths/min or greater, a partial pressure of oxygen of 70 mmHg or less, or an oxygen saturation of 92% or less were included.MEASUREMENTS: Rapid BNP and proBNP assays, performed blind at admission, were compared with the final diagnosis (CPE or no CPE) as defined by an expert team.RESULTS: Two hundred two patients (mean age +/- standard deviation 80 +/- 9) were included; 88 (44%) had CPE. There was a strong correlation between proBNP and BNP values (correlation coefficient=0.91, P