The power of price compels you: Behavioral economic insights into dopamine-based valuation of rewarding and aversively motivated behavior.
The power of price compels you: Behavioral economic insights into dopamine-based valuation of rewarding and aversively motivated behavior.
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价格的力量迫使你：对基于多巴胺的奖励和厌恶动机行为的评估的行为经济学见解。
DOI：
10.1016/j.brainres.2018.11.043
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发表时间：
2019
期刊：
影响因子：
2.9
通讯作者：
Roberts,JontéB
中科院分区：
文献类型：
--
作者：
Oleson,ErikB;Roberts,JontéB
中皮质边缘多巴胺通路通常被认为是一种奖赏通路。虽然目光短浅，但这种多巴胺功能的观点有很强的基础。在这里，我们首先描述的作用，阶段性多巴胺释放事件的奖励寻求。然后，我们解释了为什么这些释放事件被重新考虑为价值信号，以及我们如何应用行为经济学来确认它们在奖励评估中发挥因果作用。然而，仅仅因为多巴胺的释放可以作为多巴胺奖励值信号，并不意味着多巴胺仅仅是一种奖励分子。相反，中皮质边缘多巴胺似乎介导许多适应性行为，包括：奖励寻求，回避，逃避和恐惧相关的条件冻结。虽然还需要更多的研究才能就多巴胺何时、何地以及如何介导厌恶动机行为达成共识，但它的参与几乎是无可辩驳的。因此，我们接下来描述多巴胺在这些行为学相关的防御行为中所起的作用。最后，我们描述了我们最近的行为经济学的结果，揭示了一个因果关系的作用，多巴胺的价值回避。
The mesocorticolimbic dopamine pathway is generally considered to be a reward pathway. While shortsighted, there is a strong basis for this view of dopamine function. Here, we first describe the role of phasic dopamine release events in reward seeking. We then explain why these release events are being reconsidered as value signals and how we applied behavioral economics to confirm they play a causal role in the valuation of reward. Just because dopamine release can function as a dopamine reward value signal however, does not imply that dopamine is solely a reward molecule. Rather, mesocorticolimbic dopamine appears to mediate many adaptive behaviors, including: reward seeking, avoidance, escape and fear-associated conditioned freezing. While more studies are needed before a consensus is reached on when, where and how dopamine mediates aversively-motivated behavior, its involvement is almost irrefutable. Thus, we next describe the role dopamine plays in these ethologically-relevant defensive behaviors. We conclude by describing our recent behavioral economics results that reveal a causal role for dopamine in the valuation of avoidance.