Genetic mapping of lysyl oxidase-2 (Loxl) on mouse chromosome 9.
Genetic mapping of lysyl oxidase-2 (Loxl) on mouse chromosome 9.
复制标题
小鼠 9 号染色体上赖氨酰氧化酶 2 (Loxl) 的遗传图谱。
DOI：
10.1007/s003359900520
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Kingsmore,SF
中科院分区：
文献类型：
--
作者：
Tchernev,VT;Yang,TP;Kingsmore,SF
Discussion: cDNA clones corresponding to human LOXL were originally identified by screening a human lung [3] and human umbilical artery [2] eDNA library with a human lysyl oxidase (LOX) or mouse lysyl oxidase (Lox) cDNA probe, respectively. Lysyl oxidase catalyzes the oxidative deamination of e-amino groups of peptidyMysine or peptidyl-hydroxylysine residues in tropocollagen, and peptidyl-lysine residues of tropoelastin. These deaminations initiate the covalent cross-linking of both collagen and elastin in the extracellular matrix. Mouse lysyl oxidase has also been reported to be associated with ras-mediated tumor suppression [4]. The function of the LOXL protein is currently unknown. Human LOXL is encoded by seven exons. Five of these encode the portion of LOXL that corresponds to the mature secreted form of human LOX, including the catalytic domain [5]. This region of LOXL is highly conserved with LOX (76% amino acid identity), suggesting that LOXL may also possess amine oxidase activity and may represent a variant of LOX. The mouse Loxl eDNA was identified from a mouse lung cDNA library using a human LOXL cDNA probe.
