Reliability and reproducibility of individual differences in functional connectivity acquired during task and resting state.
Reliability and reproducibility of individual differences in functional connectivity acquired during task and resting state.
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DOI：
10.1002/brb3.456
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发表时间：
2016-05
影响因子：
3.1
通讯作者：
Anderson JS
中科院分区：
文献类型：
--
作者：
Shah LM;Cramer JA;Ferguson MA;Birn RM;Anderson JS
在个体水平上将fMRI连接性指标作为诊断生物标志物的应用将需要对发育、衰老、神经认知和行为表现和病理的纵向变化的可靠性、灵敏度和特异性。这些指标还没有很好地表征BOLD收购的最新进展。使用FIX伊卡和WM、CSF和运动参数回归对HCP 500受试者发布的多波段BOLD数据进行分析。使用覆盖5 mm分辨率灰质的ROI进行分析，以评估功能连接。关键区域的ROI用于证明特定连接之间的统计差异。针对静息状态和任务获取，评价了组平均功能连接和个体单个连接的再现性。在任务和休息期间以及在不同任务期间，显示了组平均连接性的系统性差异，尽管连接性存在个体差异。一个单一的连接为主题和跨主题的休息和任务采集的再现被证明是成像时间的平方根的线性函数。随机删除高达50%的时间点对可靠性的影响很小，而截断采集与可靠性下降。皮质内的可靠性最高，深灰色核、灰白色交界处和大脑沟附近的可靠性最低。这项研究发现了在任务和休息习得过程中获得的组平均连接性的系统差异，并由于个体大脑活动和大脑结构的内在差异而保留了连接性的个体差异。我们还表明，需要更长的扫描时间来获取特定ROI之间的连接信息的单个受试者的数据。较长的扫描可能会促进收购期间的任务范式，这将系统地影响功能的连接，但可能会保留在任务调制顶部的连接的个体差异。
Application of fMRI connectivity metrics as diagnostic biomarkers at the individual level will require reliability, sensitivity and specificity to longitudinal changes in development, aging, neurocognitive, and behavioral performance and pathologies. Such metrics have not been well characterized for recent advances in BOLD acquisition. Analysis of multiband BOLD data from the HCP 500 Subjects Release was performed with FIX ICA and with WM, CSF and motion parameter regression. Analysis with ROIs covering the gray matter at 5 mm resolution was performed to assess functional connectivity. ROIs in key areas were used to demonstrate statistical differences between specific connections. Reproducibility of group‐mean functional connectivity and for single connections for individuals was evaluated for both resting state and task acquisitions. Systematic differences in group‐mean connectivity were demonstrated during task and rest and during different tasks, although individual differences in connectivity were maintained. Reproducibility of a single connection for a subject and across subjects for resting and task acquisition was demonstrated to be a linear function of the square root of imaging time. Randomly removing up to 50% of time points had little effect on reliability, while truncating an acquisition was associated with decreased reliability. Reliability was highest within the cortex, and lowest for deep gray nuclei, gray‐white junction, and near large sulci. This study found systematic differences in group‐mean connectivity acquired during task and rest acquitisions and preserved individual differences in connectivity due to intrinsic differences in an individual's brain activity and structural brain architecture. We also show that longer scan times are needed to acquire data on single subjects for information on connections between specific ROIs. Longer scans may be facilitated by acquisition during task paradigms, which will systematically affect functional connectivity but may preserve individual differences in connectivity on top of task modulations.