PRIDE: The proteomics identifications database
PRIDE: The proteomics identifications database
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DOI：
10.1002/pmic.200401303
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发表时间：
2005-08-01
期刊：
影响因子：
3.4
通讯作者：
Apweiler, R
中科院分区：
文献类型：
--
作者：
Martens, L;Hermjakob, H;Apweiler, R
高通量蛋白质组学的出现使蛋白质数量不断增加。相应地，以这些蛋白质识别为中心的出版物数量显着增加。随着HUPO等离子体蛋白质组项目的第一个结果以及许多其他大规模蛋白质组学项目即将传播其数据，因此这种趋势不太可能很快就会弄平。但是，这些确定的蛋白质的出版机制在技术方面落后。通常，识别的列表通常直接与文章一起发布，从而导致了大量且相当乏味的读物，或者以补充信息包含在出版商的网站上。无论哪种情况，这些列表通常仅作为具有自定义布局的便携式文档格式文档提供，这几乎使计算机程序无法解释它们，更不用说有效地查询它们了。在这里，我们提出了蛋白质组学识别（PRIDE）数据库（http://www.ebi.ac.uk/pride），作为最终将公开可用数据转变为公共访问数据的手段。 PRIDE提供了基于Web的查询接口，用户友好的数据上传功能以及用于直接计算访问的已记录的应用程序编程接口。完整的PRIDE数据库，源代码，数据和支持工具可自由使用，用于Web访问或下载和本地安装。
The advent of high-throughput proteomics has enabled the identification of ever increasing numbers of proteins. Correspondingly, the number of publications centered on these protein identifications has increased dramatically. With the first results of the HUPO Plasma Proteome Project being analyzed and many other large-scale proteomics projects about to disseminate their data, this trend is not likely to flatten out any time soon. However, the publication mechanism of these identified proteins has lagged behind in technical terms. Often very long lists of identifications are either published directly with the article, resulting in both a voluminous and rather tedious read, or are included on the publisher's website as supplementary information. In either case, these lists are typically only provided as portable document format documents with a custom-made layout, making it practically impossible for computer programs to interpret them, let alone efficiently query them. Here we propose the proteomics identifications (PRIDE) database (http://www.ebi.ac.uk/pride) as a means to finally turn publicly available data into publicly accessible data. PRIDE offers a web-based query interface, a user-friendly data upload facility, and a documented application programming interface for direct computational access. The complete PRIDE database, source code, data, and support tools are freely available for web access or download and local installation.