5-AZACYTIDINE INDUCTION OF MOUSE ENDOGENOUS TYPE-C VIRUS AND SUPPRESSION OF DNA METHYLATION

5-AZACYTIDINE INDUCTION OF MOUSE ENDOGENOUS TYPE-C VIRUS AND SUPPRESSION OF DNA METHYLATION
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DOI：
10.1073/pnas.78.10.6290
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发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
通讯作者：
SUGAHARA, T
SUGAHARA, T
中科院分区：
其他
文献类型：
--
作者：
NIWA, O;SUGAHARA, T

文献摘要

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5-氮杂胞苷诱导K-BALB细胞表达BALB：virus-1和BALB：virus-2，诱导AKR 2B细胞表达亲嗜性内源性病毒。诱导效率高，与5-溴脱氧尿苷相当。5-氮胞苷处理K-BALB细胞后，新合成的DNA中甲基胞嘧啶的水平显著降低。DNA修饰水平与病毒表达频率呈负相关。
5-Azacytidine induced the expression of BALB:virus-1 and BALB:virus-2 from K-BALB cells and ecotropic endogenous virus from AKR2B cells. Efficiency of the induction was high and comparable to that by 5-bromodeoxyuridine. The level of methylcytosine in newly synthesized DNA was drastically decreased when K-BALB cells were treated with 5-azacytidine. There was an inverse relationship between the level of DNA modification and the frequency of virus expression.