Apparent Diffusion Coefficient: Prostate Cancer Versus Noncancerous Tissue According to Anatomical Region
Apparent Diffusion Coefficient: Prostate Cancer Versus Noncancerous Tissue According to Anatomical Region
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DOI：
10.1002/jmri.21513
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发表时间：
2008-11-01
影响因子：
4.4
通讯作者：
Cho, Kyoung-Sik
中科院分区：
文献类型：
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作者：
Kim, Jeoung Hyun;Kim, Jeong Kon;Cho, Kyoung-Sik
目的：材料与方法：对47例前列腺癌患者进行1.5T磁共振弥散加权成像（b值为0和1000 see/mm 2），测量其表观扩散系数（ADC）值，并对3种非癌组织（移行区、外周区和前列腺基底部）进行ADC值测量。结果：前列腺癌的平均ADC值（0.963 × 10 ~（-3）mm ~（2）/s）明显低于所有非癌组织（P < 0.001）;在非癌组织中，ADC值随解剖部位不同而不同（外周区1.572 × 10 ~（-3）mm ~（2）/sec，移行区1.441 × 10 ~（-3）mm ~（2）/sec，前列腺基底部1.146 × 10 ~（-3）mm ~（2）/sec）（P < 0.01）。34例（72%）前列腺癌的ADC值低于所有癌旁组织。区分前列腺基底部癌与非癌的ROC曲线下面积（0.725）小于区分前列腺周围部癌与非癌的ROC曲线下面积（0.952）和区分前列腺移行区癌与非癌的ROC曲线下面积（0.906）（P < 0.05）。不同解剖部位ADC值的敏感性不同（边缘区98%，移行区82%，前列腺基底部66%）（P < 0.05）。
Purpose: To evaluate diagnostic performance of apparent diffusion coefficient (ADC) in differentiating prostate cancer from noncancerous tissue according to anatomical region.Materials and Methods: In 47 patients with diffusion-weighted-MR (b-value, 0 and 1000 see/mm(2)) on a 1.5 T unit, ADCs were measured in prostate cancer and in three noncancerous tissues (transitional zone, peripheral zone, and prostatic base). Diagnostic performance of ADC for differentiating cancer from noncancerous tissue was evaluated using receiver-operating-characteristics (ROC) analysis.Results: Mean ADC of prostate cancer (0.963 X 10(-3) mm(2)/s) was lower than those of all noncancerous tissues (P < 0.001). In noncancerous tissue, ADC differed according to anatomical region (peripheral zone, 1.572 X 10(-3) mm(2)/sec: transitional zone, 1.441 X 10-3 mm(2)/sec; prostatic base, 1.146 X 10(-3) mm(2)/sec) (P < 0.01). ADC was lower in prostate cancer than in all noncancerous tissues In 34 (72%) patients. Area under the ROC curve for differentiating cancer from noncancerous tissue in prostatic base (0.725) was less than those for differentiating cancer from noncancerous tissue in peripheral (0.952) and transitional zones (0.906) (P < 0.05). Sensitivity differed according to anatomical region (peripheral zone, 98%: transitional zone, 82%; prostatic base, 66%) (P < 0.05).Conclusion: Variable ADC in noncancerous tissue according to anatomical region may limit diagnostic performance of ADC for cancer detection.