Iron levels in human retina: sex difference and increase with age
Iron levels in human retina: sex difference and increase with age
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DOI：
10.1097/wnr.0b013e3280107776
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发表时间：
2006-11-27
期刊：
影响因子：
1.7
通讯作者：
Dunaief, Joshua L.
中科院分区：
文献类型：
--
作者：
Hahn, Paul;Ying, Gui-shuang;Dunaief, Joshua L.
氧化应激被认为在生理衰老和年龄相关疾病中是重要的。铁是一种有效的促氧化剂，与几种与年龄有关的疾病有关。虽然血清铁蛋白，作为体内铁储存的估计，已被证明随着年龄的增长而增加，但很少有研究直接涉及年龄对人类神经组织铁水平的影响。我们用原子吸收分光光度法定量评估铁水平的眼睛结构，视网膜和视网膜色素上皮细胞/脉络膜的正常人的眼睛的不同年龄和性别。我们发现视网膜铁随年龄增长而增加，与血清铁蛋白水平相似。在所有年龄段，女性的视网膜铁含量都高于男性，这表明铁的调节可能存在性别特异性影响。
Oxidative stress is believed to be important in physiological aging and age-related diseases. Iron is a potent pro-oxidant implicated in several age-related diseases. While serum ferritin, as an estimate of body stores of iron, has been shown to increase with age, few studies have directly addressed the effect of age on human neural tissue iron levels. We used atomic absorption spectrophotometry to assess quantitatively iron levels within the eye structures, retina and retinal pigment epithelium/choroid of normal human eyes of various ages and of both sexes. We found that retinal iron increases with age, similar to serum ferritin levels. Women had more retinal iron than men at all ages, suggesting that there may be gender-specific influences on iron regulation.