Scabrolides A-D, four new norditerpenoids isolated from the soft coral Sinularia scabra
Scabrolides A-D, four new norditerpenoids isolated from the soft coral Sinularia scabra
复制标题
DOI：
10.1021/np020280r
复制
发表时间：
2002-12-01
影响因子：
5.1
通讯作者：
Kuo, YH
中科院分区：
文献类型：
--
作者：
Sheu, JH;Ahmed, AF;Kuo, YH
从台湾软珊瑚 Sinulariascabra 的二氯甲烷提取物中分离出了四种新的去甲二萜类化合物 scabrolides A-D (1-4) 以及四种已知的化合物 5-8。 1-4的结构是在广泛的光谱分析的基础上阐明的，而相对构型是通过NOESY实验确定的。差向代谢物 6 和 7 已被证明对 KB 和 Hepa59T/VGH 癌细胞系表现出强细胞毒活性。
Four new norditerpenoids, scabrolides A-D (1-4), along with four known ones, 5-8, have been isolated from the dichloromethane extract of the Taiwanese soft coral Sinularia scabra. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses, while the relative configurations were determined by the NOESY experiments. The epimeric metabolites 6 and 7 have been shown to exhibit strong cytotoxic activity against KB and Hepa59T/VGH cancer cell lines.