Imaging Essential Tremor
Imaging Essential Tremor
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DOI：
10.1002/mds.22870
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发表时间：
2010-04-30
影响因子：
8.6
通讯作者：
Antonini, Angelo
中科院分区：
文献类型：
--
作者：
Isaias, Ioannis U.;Marotta, Giorgio;Antonini, Angelo
为了研究纹状体多巴胺转运蛋白（DAT）随时间的变化，我们对20名原发性震颤（ET）受试者、13名帕金森病（PD）受试者和23名健康对照（HC，仅一次扫描）进行了两次连续的N-ω-氟丙基-2 β-甲氧羰基-3 β-（4-碘苯基）托烷单光子计算机断层扫描（SPECT）。我们还对9例ET、第二组18例PD（9例震颤，tPD和9例运动不能-强直显性，arPD）和8例HC进行了[Tc-99 m]乙基半胱氨酸二聚体双水杨酸SPECT检查，以进行局部脑网络分析。与ET和HC相比，PD受试者的DAT结合减少，对侧壳核的年下降率为7.3%。基线时ET和HC之间无平均摄取差异，ET中无随时间推移的摄取丢失。判别分析将30%（第一次扫描）和5%（第二次扫描）的ET分组为PD，分区分析显示尾状核摄取的ET和PD之间存在重叠。空间协方差分析显示，PD相关区域模式的表达将tPD和arPD与ET和HC分开。总之，PD和ET没有共同的模式，多巴胺能损失随着时间的推移。然而，尾状核多巴胺转运蛋白的轻度损伤可能有助于震颤发作的ET。(C)2010年运动障碍协会
To investigate over time changes in striatal dopamine transporter (DAT), we performed two sequential N-omega-fluoropropyl-2 beta-carbomethoxy-3 beta-(4-iodophenyl) tropane single photon computed tomography (SPECT) scans in 20 subjects with essential tremor (ET), in 13 with Parkinson disease (PD) and in 23 healthy controls (HC, one scan only). We also performed an [Tc-99m]ethyl cysteinate dimer bicisate SPECT exam for regional brain network analysis in 9 ET, in a second group of 18 PD (9 with tremor, tPD and 9 akinetic-rigid dominant, arPD) and in 8 HC. PD subjects had a reduced DAT binding in comparison to ET and HC with an annual decline rate of 7.3% in the contralateral putamen. There were no mean uptake differences between ET and HC at baseline and no uptake loss over time in ET. A discriminant analysis grouped 30% (first scan) and 5% (second scan) of ET as PD and a partition analysis showed overlap between ET and PD for caudate nucleus uptake. Spatial covariance analysis revealed that the expression of the PD-related regional pattern separated both tPD and arPD from ET and HC. In conclusion, PD and ET do not share a common pattern of dopaminergic loss over time. However, mild impairment of dopamine transporter in the caudate nucleus may contribute to tremor onset in ET. (C) 2010 Movement Disorder Society