Long-term seizure freedom following intracranial sEEG monitoring: Therapeutic benefit of a diagnostic technique
Long-term seizure freedom following intracranial sEEG monitoring: Therapeutic benefit of a diagnostic technique
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DOI：
10.1016/j.ebr.2019.100345
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发表时间：
2019-01-01
影响因子：
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通讯作者：
Jaisani, Zeenat
中科院分区：
文献类型：
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作者：
Kaur, Manmeet;Szaflarski, Jerzy P.;Jaisani, Zeenat
患有难治性癫痫的患者通常需要手术。TRE患者在sEEG侵入性监测后无需进一步切除或神经调节即可自发持续无癫痫发作是非常罕见的。在过去5年监测的78例TRE病例中，我们确定了3例在sEEG监测后无复发的患者，未进行进一步切除或神经调节。即使不进行进一步干预，sEEG后无癫痫发作也是可能的。在完成侵入性监测后未观察到癫痫发作的情况下，在计划的神经调节或切除之前，电极复位后需要更长的观察期。这可能是由于沿着和电极束周围的组织损伤局灶性区域导致皮质-皮质下癫痫网络中断。(C)2019作者爱思唯尔公司出版
Patients with treatment-resistant epilepsy often require surgery. It is very rare that patients with TRE can have sustained seizure freedom spontaneously, without undergoing further resection or neuro-modulation after invasive monitoring with sEEG. Of the 78 TRE cases monitored over last 5 years, we identified three patients who became seizure-free following sEEG monitoring without undergoing further resection or neuro-modulation. Seizure-freedom after sEEG is possible even without further intervention. In cases where seizures after the completion of the invasive monitoring are not observed, a longer observation period following electrode explantation prior to planned neuro-modulation or resection is warranted. This could be due to the disruption of the cortical-subcortical epileptogenic network due to focal area of tissue damage along and around the electrode tract. (C) 2019 The Authors. Published by Elsevier Inc.