Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds.
Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds.
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DOI：
10.1042/bcj20200894
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发表时间：
2021-04
期刊：
影响因子：
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通讯作者：
MD Khurshidul Zahid;Hazera Binte Sufian;M. Choudhury;M. Yamasaki;A. Al‐Harrasi;N. Moustaid‐Moussa;
中科院分区：
文献类型：
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作者：
MD Khurshidul Zahid;Hazera Binte Sufian;M. Choudhury;M. Yamasaki;A. Al‐Harrasi;N. Moustaid‐Moussa;
动脉粥样硬化是一种与脂代谢紊乱相关的慢性炎症性疾病。自噬是一种分解代谢过程，有助于维持细胞内环境的稳定。大量证据表明，自噬缺陷与包括动脉粥样硬化在内的几种疾病有关，而自噬增加则可缓解动脉粥样硬化的发展。因此，了解自噬调节的机制及其与动脉粥样硬化的关系对于开发抗动脉粥样硬化的新疗法是至关重要的。膳食生物活性化合物是非营养的天然化合物，包括酚类、类黄酮类和类胡萝卜素。重要的是，这些生物活性化合物具有抗炎、抗氧化和抗菌特性，可以缓解各种慢性病。最近，研究生物活性化合物在动脉粥样硬化形成中对自噬活性的影响引起了相当大的关注。现就巨噬细胞自噬在动脉粥样硬化发生发展中的作用作一综述。我们还总结了目前关于生物活性化合物在动脉粥样硬化和自噬方面的治疗潜力的知识。
Atherosclerosis is a chronic inflammatory disease associated with lipid metabolism disorder. Autophagy is a catabolic process and contributes to maintaining cellular homeostasis. Substantial evidence suggests that defective autophagy is implicated in several diseases, including atherosclerosis, while increased autophagy mitigates atherosclerosis development. Thus, understanding the mechanisms of autophagy regulation and its association with atherosclerosis is vital to develop new therapies against atherosclerosis. Dietary bioactive compounds are non-nutrient natural compounds that include phenolics, flavonoids, and carotenoids. Importantly, these bioactive compounds possess anti-inflammatory, antioxidant, and antibacterial properties that may alleviate various chronic diseases. Recently, examining the effects of bioactive compounds on autophagy activity in atherogenesis has drawn considerable attention. The current review discusses the role of macrophage autophagy in the development and progression of atherosclerosis. We also summarize our current knowledge of the therapeutic potential of bioactive compounds on atherosclerosis and autophagy.