Vibrational spectroscopic changes of B-lymphocytes upon activation.
Vibrational spectroscopic changes of B-lymphocytes upon activation.
复制标题
B 淋巴细胞激活后的振动光谱变化。
DOI:
10.1002/jbio.201200136
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发表时间:
2013
影响因子:
2.8
通讯作者:
Bird,Benjamin
中科院分区:
文献类型:
--
作者:
Mazur,AntonellaI;Monahan,JenniferL;Miljkovic,Milos;Laver,Nora;Diem,Max;Bird,Benjamin
The first study interpreting B‐lymphocyte activation in normal lymph nodes using vibrational micro‐spectral imaging is reported. Lymphocyte activation indicates the presence and response against a pathogen, regardless of the inciting pathogen's etiology, whether a benign, reactive or malignant process. Understanding the biochemical makeup of lymphocyte activation during early stages of disease and immune response may offer significant aid in determining a tumor's origin without the presence of malignant metastatic cells but within lymph nodes that are reactive and displaying regions of hyperplasia. Infrared and Raman data scrutinizedviaunsupervised multivariate methods may provide a physical and reproducible method to determine the biochemical components and variances therein of activated lymph nodes with distinguishing characteristics depending on the malignancy present in the region or elsewhere in the body. The results reported here provide a proof‐of‐concept study that reveal a potential to screen lymph nodes for disease without the presence of metastatic cells. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
影响因子:
2.9
作者:
D. Hewage;M. Roudjane;Ruchira Silva;S. Kumari;Dong
通讯作者:
Dong
DOI:
--
发表时间:
1990
期刊:
影响因子:
--
作者:
T. Marks
通讯作者:
T. Marks