The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase
The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase
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DOI：
10.1038/nsmb1216
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发表时间：
2007-04-01
影响因子：
16.8
通讯作者：
Zhang, Yi
中科院分区：
文献类型：
--
作者：
Lee, Nara;Zhang, Junyu;Zhang, Yi
最近的研究表明，可以通过主动脱甲基化动态调节组蛋白甲基化。但是，尚未鉴定出针对组蛋白H3三甲基溶解酶4（H3K4ME3）的脱甲基酶。在这里，我们报告说，果蝇果蝇蛋白“ Little Imaginal Discs”（LID）是一种含JMJC结构域的Trithorax群蛋白，可以脱甲基化H3K4Me3。与其遗传分类一致，盖子阳性调节了S2细胞中HOX基因的表达。
Recent studies have demonstrated that histone methylation can be dynamically regulated through active demethylation. However, no demethylase specific to histone H3 trimethyl-Lys4 (H3K4me3) has been identified. Here we report that the Drosophila melanogaster protein 'little imaginal discs' (Lid), a JmjC domain-containing trithorax group protein, can demethylate H3K4me3. Consistent with its genetic classification, Lid positively regulates Hox gene expression in S2 cells.