Study methods, recruitment, sociodemographic findings, and demographic representativeness in the OPPERA study.

Study methods, recruitment, sociodemographic findings, and demographic representativeness in the OPPERA study.
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DOI:
10.1016/j.jpain.2011.08.001
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发表时间:
2011-11
期刊:
The journal of pain
影响因子:
--
通讯作者:
Ohrbach R
Ohrbach R
中科院分区:
其他
文献类型:
--
作者:
Slade GD;Bair E;By K;Mulkey F;Baraian C;Rothwell R;Reynolds M;Miller V;Gonzalez Y;Gordon S;Ribeiro-Dasilva M;Lim PF;Greenspan JD;Dubner R;Fillingim RB;Diatchenko L;Maixner W;Dampier D;Knott C;Ohrbach R

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本文介绍了“口面疼痛前瞻性评价和风险评估”(OPPERA)项目中使用的方法,并在OPPERA病例对照研究中评价了与颞下颌关节紊乱病(TMD)相关的社会人口学特征。通过比较OPPERA参与者的社会人口学资料与研究地点附近县的人口普查资料,并通过比较OPPERA和2007-09年美国国家健康访谈调查中年龄和性别与TMD的相关性,调查了代表性。在美国的四个研究中心招募了18-44岁的志愿者:3,263名无TMD的人参加了前瞻性队列研究;其中1,633人被选为基线病例对照研究的对照。研究对象为185例经检查者确诊的TMD患者。OPPERA参与者的一些人口特征的分布与人口普查概况不同,尽管社会经济概况的差异较小。在18-44岁的年龄范围内,TMD的几率与年龄较大有关;女性TMD的几率是男性的三倍;相对于非西班牙裔白人,其他种族群体TMD的几率是五分之一。年龄和性别与慢性TMD的相关性与美国人群中观察到的相关性惊人相似。在这个人口统计学上多样化的社区志愿者群体的代表性评估表明,OPPERA病例对照研究结果具有良好的内部效度。
This paper describes methods used in the project “Orofacial Pain Prospective Evaluation and Risk Assessment” (OPPERA) and evaluates socio-demographic characteristics associated with temporomandibular disorders (TMD) in the OPPERA case-control study. Representativeness was investigated by comparing socio-demographic profiles of OPPERA participants with population census profiles of counties near study sites and by comparing age- and gender-associations with TMD in OPPERA and the 2007-09 US National Health Interview Survey. Volunteers aged 18-44 years were recruited at four US study sites: 3,263 people without TMD were enrolled into the prospective cohort study; 1,633 of them were selected as controls for the baseline case-control study. Cases were 185 volunteers with examiner-classified TMD. Distributions of some demographic characteristics among OPPERA participants differed from census profiles, although there was less difference in socio-economic profiles. Odds of TMD was associated with greater age in this 18-44 year range; females had three times the odds of TMD as males; and relative to non-Hispanic-Whites, other racial groups had one-fifth the odds of TMD. Age- and gender-associations with chronic TMD were strikingly similar to associations observed in the US population. Assessments of representativeness in this demographically diverse group of community volunteers suggest that OPPERA case-control findings have good internal validity.
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