Childhood exposure to violence and lifelong health: Clinical intervention science and stress-biology research join forces
Childhood exposure to violence and lifelong health: Clinical intervention science and stress-biology research join forces
复制标题
DOI：
10.1017/s0954579413000801
复制
发表时间：
2013-11-01
影响因子：
3.3
通讯作者：
Moffitt, Terrie E.
中科院分区：
文献类型：
--
作者：
Moffitt, Terrie E.
许多被成年人虐待的年轻人，被欺凌者，犯罪袭击的受害者，或者目睹家庭暴力的年轻人通过发展行为，情感或学习问题来应对这种暴力暴露。鲜为人知的是，暴力等不良经历可能会导致儿童体内隐藏的身体变化，这些变化可能会对终生健康产生不利影响。我们讨论了为什么这对发展精神病理学和社会领域很重要，我们建议压力生物学研究和干预科学联合起来解决这个问题。我们研究了与身体（炎症反应，端粒侵蚀，表观遗传甲基化和基因表达）和大脑（精神障碍，神经影像学和神经心理学测试）的压力敏感措施有关的证据基础。我们还审查了有希望的干预措施，为家庭，夫妇和儿童，旨在减少儿童暴力暴露的影响。我们邀请干预科学家和压力生物学研究人员合作，在旨在减少暴力暴露和其他创伤对年轻人影响的干预措施的随机临床试验中加入压力生物学措施。
Many young people who are mistreated by an adult, victimized by bullies, criminally assaulted, or who witness domestic violence react to this violence exposure by developing behavioral, emotional, or learning problems. What is less well known is that adverse experiences like violence exposure can lead to hidden physical alterations inside a child's body, alterations that may have adverse effects on life-long health. We discuss why this is important for the field of developmental psychopathology and for society, and we recommend that stress-biology research and intervention science join forces to tackle the problem. We examine the evidence base in relation to stress-sensitive measures for the body (inflammatory reactions, telomere erosion, epigenetic methylation, and gene expression) and brain (mental disorders, neuroimaging, and neuropsychological testing). We also review promising interventions for families, couples, and children that have been designed to reduce the effects of childhood violence exposure. We invite intervention scientists and stress-biology researchers to collaborate in adding stress-biology measures to randomized clinical trials of interventions intended to reduce effects of violence exposure and other traumas on young people.