CONTROLLED RELEASE OF DOPAMINE FROM A POLYMERIC BRAIN IMPLANT - INVIVO CHARACTERIZATION
CONTROLLED RELEASE OF DOPAMINE FROM A POLYMERIC BRAIN IMPLANT - INVIVO CHARACTERIZATION
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DOI：
10.1002/ana.410250406
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发表时间：
1989-04-01
影响因子：
11.2
通讯作者：
LANGER, R
中科院分区：
文献类型：
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作者：
DURING, MJ;FREESE, A;LANGER, R
脑内微透析用于评估纹状体植入后长达 65 天的乙烯-醋酸乙烯酯 (EVAc)-多巴胺共聚物基质盘中多巴胺的长期体内释放。多巴胺的释放是通过椎间盘一侧的单个空腔进行的，否则该空腔完全涂有一层额外的、不渗透的EVAc层。植入装置 20 天后，纹状体内的细胞外多巴胺浓度达到微摩尔水平，比对照值高 200 倍以上。多巴胺的释放在两个月的实验期间表现出稳定和维持。组织学检查证实了植入物的生物相容性。这项技术有可能应用于治疗帕金森病以及其他神经和精神疾病。
Intracerebral microdialysis was used to evaluate the long-term in vivo release of dopamine form ethylene-vinyl acetate (EVAc)-dopamine copolymer matrix disc for up to 65 days following striatal implantation. Dopamine release occurred through a single cavity present on one side of the disc, which was otherwise fully coated with an additional, impermeable layer of EVAc. At 20 days following implantation of the device, extracellular concentrations of dopamine within the striatum reached micromolar levels, over 200-fold greater than control values. Release of dopamine was shown to be stable and maintained for the 2-month duration of the experiment. Histological examination confirmed the biocompatible nature of the implant. There are potential applications of this technology to the treatment of Parkinson''s disease and other neurological and psychiatric disorders.