Strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila
Strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila
复制标题
DOI：
10.1101/gad.11.10.1341
复制
发表时间：
1997-05-15
影响因子：
10.5
通讯作者：
Banerjee, U
中科院分区：
文献类型：
--
作者：
Majumdar, A;Nagaraj, R;Banerjee, U
果蝇翅盘的背/腹（D/V）边界在果蝇翅盘的生长和图案形成中起着组织者的作用，并在成年果蝇中产生翅缘。在这里，我们表明，草莓缺口（sno）是一个下游组件的Notch信号通路，是重要的规格，这一组织者。sno编码一个新的核蛋白，该蛋白在C. elegans线虫，mouse小鼠，and humans人.翅缘基因的突变主要与sno相互作用，sno功能的丧失导致无翅、退化、切割和E（spl）-m8在D/V边界的表达丧失。在调节这些基因时，sno与无毛抑制因子和无毛抑制因子密切合作。最后，sno在侧抑制中没有作用，这表明它可能有助于侧抑制和诱导Notch信号通路之间的特异性。
The dorsal/ventral (D/V) boundary functions as an organizer in the growth and patterning of the Drosophila wing disc and gives rise to the wing margin in the adult fly. Here we show that strawberry notch (sno) is a downstream component of the Notch signaling pathway and is important for the specification of this organizer. sno encodes a novel nuclear protein conserved in C. elegans, mouse, and humans. Mutations in wing margin genes interact dominantly with sno and loss of sno function results in loss of expression of wingless, vestigial, cut, and E(spl)-m8 at the D/V boundary. In regulating these genes, sno functions in close cooperation with Suppressor of Hairless and Hairless. Finally, sno has no role in lateral inhibition suggesting that it may contribute to the specificity between lateral and inductive Notch signaling pathways.