Progress in Bioengineered Whole Tooth Research: From Bench to Dental Patient Chair.
Progress in Bioengineered Whole Tooth Research: From Bench to Dental Patient Chair.
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DOI：
10.1007/s40496-016-0110-2
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发表时间：
2016-12
影响因子：
--
通讯作者：
Yelick PC
中科院分区：
文献类型：
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作者：
Smith EE;Yelick PC
牙齿脱落是一个重要的健康问题，影响日常生活的生理和社会方面。牙齿缺失会影响咀嚼和说话的简单任务，也会导致自信心下降。基于再生医学的牙科研究的一个新兴和令人兴奋的领域集中在生物工程全牙替代疗法的形成，可以提供天然牙齿的功能和感觉反应。该研究领域旨在提高牙齿和口腔健康的质量，为那些患有牙齿脱落。目前的方法使用牙齿祖细胞，支架和生长因子的组合来创建基于生物学的替代牙齿，以作为目前使用的人工牙齿修复的改进替代品。本文就生物工程全牙的研究现状、面临的挑战及未来的临床应用作一综述。
Tooth loss is a significant health issue that affects the physiological and social aspects of everyday life. Missing teeth impair simple tasks of chewing and speaking, and can also contribute to reduced self-confidence. An emerging and exciting area of regenerative medicine based dental research focuses on the formation of bioengineered whole tooth replacement therapies that can provide both the function and sensory responsiveness of natural teeth. This area of research aims to enhance the quality of dental and oral health for those suffering from tooth loss. Current approaches use a combination of dental progenitor cells, scaffolds and growth factors to create biologically based replacement teeth to serve as improved alternatives to currently used artificial dental prosthetics. This article is an overview of current progress, challenges, and future clinical applications of bioengineered whole teeth.