Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference
Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference
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DOI：
10.1007/s10995-012-1031-x
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发表时间：
2013-04-01
影响因子：
2.3
通讯作者：
Mikovic, Zeljko
中科院分区：
文献类型：
--
作者：
Zeljkovic, Aleksandra;Vekic, Jelena;Mikovic, Zeljko
怀孕与低密度脂蛋白（LDL）和高密度脂蛋白（HDL）亚类的变化有关，但这些变化的确切模式仍然存在争议。本研究调查了正常妊娠过程中血浆低密度脂蛋白和高密度脂蛋白颗粒分布的纵向变化，以及分娩前母体低密度脂蛋白和高密度脂蛋白亚类分布与新生儿体型参数的关系。从 41 名健康孕妇的整个怀孕期间、分娩前和产后 7 周采集了血液样本。 LDL和HDL亚类通过梯度凝胶电泳测定，而其他生化参数通过标准实验室方法测量。妊娠期间，由于 LDL I (P < 0.01) 相对比例的减少以及 LDL II (P < 0.001) 和 IIIA (P < 0.05) 亚类的增加，LDL 大小显着下降 (P < 0.001)。同时，HDL 2a 颗粒的大小和比例显着下降（P < 0.001），同时 HDL 3b 和 3c 亚类增加（P < 0.05）。观察到的变化与血清甘油三酯水平的变化相关。妊娠期间 LDL 亚类分布的重排是短暂的，而产后 HDL 亚类分布仍然向更小的颗粒移动。分娩前母体血浆中 LDL IVB 比例较高是新生儿体重和身长较小的独立预测因素，而 LDL IVB 和 HDL 2a 亚类比例较高是新生儿头围较小的独立决定因素。正常妊娠期间的常规妊娠和产前护理可以通过评估低密度脂蛋白和高密度脂蛋白颗粒分布来补充，以确保新生儿有足够的大小。
Pregnancy is associated with alterations in low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses, but the exact pattern of these variations remains controversial. This study investigates longitudinal changes of plasma LDL and HDL particles distributions during the course of normal pregnancy, as well as associations of maternal LDL and HDL subclasses distributions before delivery with parameters of newborn size. Blood samples were collected from 41 healthy pregnant women throughout entire pregnancy, before delivery and 7 weeks postpartum. LDL and HDL subclasses were determined by gradient gel electrophoresis, while other biochemical parameters were measured by standard laboratory methods. During gestation LDL size significantly decreased (P < 0.001), due to reduction in relative proportion of LDL I (P < 0.01) and increase of LDL II (P < 0.001) and IIIA (P < 0.05) subclasses. In the same time, HDL size and proportions of HDL 2a particles significantly decreased (P < 0.001), with concomitant increase of HDL 3b and 3c subclasses (P < 0.05). Observed alterations were associated with changes in serum triglyceride levels. Rearrangement in LDL subclasses distribution during gestation was transient, while postpartum HDL subclasses distribution remained shifted toward smaller particles. Higher proportion of LDL IVB in maternal plasma before delivery was an independent predictor of smaller birth weights and lengths, while higher proportions of LDL IVB and HDL 2a subclasses were independent determinants of newborns' smaller head circumferences. Routine gestational and prenatal care in otherwise normal pregnancy could be complemented with evaluation of LDL and HDL particles distribution in order to ensure an adequate size of the newborn.