Selecting water-alcohol mixed solvent for synthesis of polydopamine nano-spheres using solubility parameter.
Selecting water-alcohol mixed solvent for synthesis of polydopamine nano-spheres using solubility parameter.
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DOI：
10.1038/srep06070
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发表时间：
2014-08-14
影响因子：
4.6
通讯作者：
Li M
中科院分区：
文献类型：
--
作者：
Jiang X;Wang Y;Li M
溶剂在特定的化学反应中起着重要的作用。由于自然界中的大多数反应都发生在混合溶剂体系中，因此需要一个综合的溶剂优化原则。通过计算汉森溶解度参数（HSP）距离Ra，设计了一个模型实验，探讨了混合溶剂对化学合成的影响。以水-醇体系中聚多巴胺（PDA）的合成为模型。正如预测的那样，在选定的溶剂中得到分散良好的PDA球具有较小的Ra值：甲醇/水，乙醇/水和2-丙醇/水。此外，具有较小Ra值的混合溶剂给出较高的多巴胺转化率。混合溶剂的选择策略可能有助于选择最佳的反应介质进行有效的化学合成。
The solvent plays an important role in a given chemical reaction. Since most reaction in nature occur in the mixed-solvent systems, a comprehensive principle for solvent optimization was required. By calculating the Hansen solubility parameters (HSP) distance Ra, we designed a model experiment to explore the influence of mixed solvents on the chemical synthesis. The synthesis of polydopamine (PDA) in the water-alcohol system was chosen as model. As predicted, the well-dispersed PDA spheres were obtained in selected solvents with smaller Ra values: methanol/water, ethanol/water and 2-propanol/water. In addition, the mixed solvent with smaller Ravalues gave a higher conversion of dopamine. The strategy for mixed solvent selection is might be useful to choose optimal reaction media for efficient chemical synthesis.