Publisher Correction: Ventral striatal islands of Calleja neurons control grooming in mice.
Publisher Correction: Ventral striatal islands of Calleja neurons control grooming in mice.
复制标题
出版商更正：Calleja 神经元的腹侧纹状体岛控制小鼠的梳理行为。
DOI：
10.1038/s41593-021-01003-3
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发表时间：
2022
影响因子：
25
通讯作者：
Be
中科院分区：
文献类型：
--
作者：
Zhang,Yun-Feng;VargasCifuentes,Luigim;Wright,KatherineN;Bhattarai,JanardhanP;Mohrhardt,Julia;Fleck,David;Janke,Emma;Jiang,Chunjie;Cranfill,SunaL;Goldstein,Nitsan;Schreck,Mary;Moberly,AndrewH;Yu,Yiqun;Arenkiel,BenjaminR;Be
张玉芬，LV Cifuentes，KN Wright，JP Bhattarai，J.Mohrhardt，D.Fleck，E.Janke，C.酱，SL Cranill，N.Goldstein，M.Schreck，AH Moberly，Y.Yu，BR Arenkiel，JN Betley，W.Luo，J.Stegmaier，DW Wesson，M.Spehr，MV Fuccillo和M.Ma(自然神经科学，2021[12]卷，1699-1710)。在本文最初发表的版本中，一个技术错误导致审阅者认可声明中遗漏了Christian Schreiweis。这篇文章的Html和Pdf版本中的同行评审信息部分现在已经更新，以反映她的贡献。(原始文章的以下摘要出现在Record 2022-10706-013中)。纹状体由多个分区和神经回路组成，以不同的方式控制运动输出。Calleja岛(IC)包含密集排列的颗粒细胞簇，位于腹侧纹状体，主要位于嗅结节(OT)。以D3多巴胺受体的表达为特征，IC在进化上是保守的，但具有未知的功能。在这里，我们展示了OT D3神经元的光基因激活强健地启动了小鼠的自我梳理，同时抑制了其他正在进行的行为。相反，这些神经元的光遗传抑制会阻止正在进行的梳理，而基因消融则会减少自发的梳理。此外，OT D3神经元在梳理前和梳理过程中表现出活动增加，并通过与邻近OT神经元(主要是棘突投射神经元)的突触连接影响局部纹状体输出，其放电频率显示与梳理相关的调制。我们的研究揭示了腹侧纹状体IC在调节运动输出方面的新作用，并对梳理的神经控制具有重要意义。(心理信息数据库记录(C)2022 APA，版权所有)
Reports an error in" Ventral Striatal Islands of Calleja Neurons Control Grooming in Mice" by Y.-F. Zhang, LV Cifuentes, KN Wright, JP Bhattarai, J. Mohrhardt, D. Fleck, E. Janke, C. Jiang, SL Cranfill, N. Goldstein, M. Schreck, AH Moberly, Y. Yu, BR Arenkiel, JN Betley, W. Luo, J. Stegmaier, DW Wesson, M. Spehr, MV Fuccillo and M. Ma (Nature Neuroscience, 2021 [Dec], Vol 24 [12], 1699-1710). In the version of this article initially published, a technical error led to the omission of Christiane Schreiweis from the Reviewer Recognition statement. The Peer Review Information section has now been updated in the HTML and PDF versions of the article to reflect her contributions.(The following abstract of the original article appeared in record 2022-10706-013). The striatum comprises multiple subdivisions and neural circuits that differentially control motor output. The islands of Calleja (IC) contain clusters of densely packed granule cells situated in the ventral striatum, predominantly in the olfactory tubercle (OT). Characterized by expression of the D3 dopamine receptor, the IC are evolutionally conserved, but have undefined functions. Here, we show that optogenetic activation of OT D3 neurons robustly initiates self-grooming in mice while suppressing other ongoing behaviors. Conversely, optogenetic inhibition of these neurons halts ongoing grooming, and genetic ablation reduces spontaneous grooming. Furthermore, OT D3 neurons show increased activity before and during grooming and influence local striatal output via synaptic connections with neighboring OT neurons (primarily spiny projection neurons), whose firing rates display grooming-related modulation. Our study uncovers a new role of the ventral striatum’s IC in regulating motor output and has important implications for the neural control of grooming.(PsycInfo Database Record (c) 2022 APA, all rights reserved)