Ganglion cell-inner plexiform layer and retinal nerve fiber layer thickness according to myopia and optic disc area: a quantitative and three-dimensional analysis.
Ganglion cell-inner plexiform layer and retinal nerve fiber layer thickness according to myopia and optic disc area: a quantitative and three-dimensional analysis.
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DOI：
10.1186/s12886-017-0419-1
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发表时间：
2017-03-11
影响因子：
2
通讯作者：
Jeoung JW
中科院分区：
文献类型：
--
作者：
Seo S;Lee CE;Jeong JH;Park KH;Kim DM;Jeoung JW
确定近视和视盘大小对通过谱域光学相干断层扫描 (OCT) 获得的神经节细胞内丛状层 (GCIPL) 和视乳头周围视网膜神经纤维层 (RNFL) 厚度剖面的影响。招募了 168 名年轻近视受试者的 168 只眼睛，并根据其等效球镜 (SE) 值和视盘面积分配到三组之一。所有患者均接受了 Cirrus HD-OCT 成像。通过多重比较和线性回归分析评估近视和视盘大小对 GCIPL 和 RNFL 厚度分布的影响。构建了对应于近视和视盘尺寸的不同组合的 GCIPL 和 RNFL 厚度的三维曲面图。与低度近视相比，高度近视的每个象限 RNFL 厚度及其总体平均值均显着变薄，颞象限除外（所有 Ps ≤ 0.003）。高度近视患者的平均和全区域 GCIPL 明显薄于中度和/或低度近视患者（所有 Ps ≤ 0.002）。通过线性回归分析，平均 OCT RNFL 厚度与 SE（0.81 μm/屈光度，P<0.001）、眼轴长度（-1.44 μm/mm，P<0.001）和视盘面积（5.35 μm/mm2，P<0.001）显着相关。对于OCT GCIPL参数，平均GCIPL厚度与SE（0.84μm/屈光度，P< 0.001）和眼轴长度（-1.65μm/mm，P< 0.001）显着相关。平均 GCIPL 厚度与视盘面积没有显着相关性。三维曲线显示，较大的视盘与平均 RNFL 厚度增加相关，而近视程度较高的眼睛与平均 GCIPL 和 RNFL 厚度减少相关。近视可显着影响 GCIPL 和 RNFL 厚度轮廓，视盘大小对 RNFL 厚度有显着影响。目前用于评估青光眼的 OCT 图应在考虑屈光状态和视盘大小的情况下进行分析。
To determine the influences of myopia and optic disc size on ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (RNFL) thickness profiles obtained by spectral domain optical coherence tomography (OCT). One hundred and sixty-eight eyes of 168 young myopic subjects were recruited and assigned to one of three groups according to their spherical equivalent (SE) values and optic disc area. All underwent Cirrus HD-OCT imaging. The influences of myopia and optic disc size on the GCIPL and RNFL thickness profiles were evaluated by multiple comparisons and linear regression analysis. Three-dimensional surface plots of GCIPL and RNFL thickness corresponding to different combinations of myopia and optic disc size were constructed. Each of the quadrant RNFL thicknesses and their overall average were significantly thinner in high myopia compared to low myopia, except for the temporal quadrant (all Ps ≤0.003). The average and all-sectors GCIPL were significantly thinner in high myopia than in moderate- and/or low-myopia (all Ps ≤0.002). The average OCT RNFL thickness was correlated significantly with SE (0.81 μm/diopter, P < 0.001), axial length (-1.44 μm/mm, P < 0.001), and optic disc area (5.35 μm/mm2, P < 0.001) by linear regression analysis. As for the OCT GCIPL parameters, average GCIPL thickness showed a significant correlation with SE (0.84 μm/diopter, P < 0.001) and axial length (-1.65 μm/mm, P < 0.001). There was no significant correlation of average GCIPL thickness with optic disc area. Three-dimensional curves showed that larger optic discs were associated with increased average RNFL thickness and that more-myopic eyes were associated with decreased average GCIPL and RNFL thickness. Myopia can significantly affect GCIPL and RNFL thickness profiles, and optic disc size has a significant influence on RNFL thickness. The current OCT maps employed in the evaluation of glaucoma should be analyzed in consideration of refractive status and optic disc size.