Innate Immunity in Cancer Biology and Therapy.
Innate Immunity in Cancer Biology and Therapy.
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DOI：
10.3390/ijms241411233
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发表时间：
2023-07-08
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
包括适应性免疫检查点抑制剂（ICIs）和嵌合抗原受体（CAR）T细胞在内的免疫疗法已在临床上发展出癌症的治疗方法，其中大多数侧重于激活T细胞免疫。尽管这些策略获得了前所未有的临床反应，但只有有限的癌症患者亚群可以获得长期益处，这凸显了为肿瘤免疫治疗新时代确定新靶点的需求。先天免疫已被证明在肿瘤微环境（TME）中发挥决定性作用并影响肿瘤患者的临床结果。对浸润肿瘤的先天免疫细胞的彻底理解将有助于开发新的疗法。在这篇综述中，我们概述了先天免疫在 TME 中的作用和机制。此外，我们在基础和临床研究中讨论基于先天免疫的癌症免疫疗法。最后，我们总结了充分激发先天免疫反应的挑战以及提高抗肿瘤疗效的相应策略和措施。这篇综述可以帮助理解先天免疫，并激发创造用于治疗癌症的全新免疫疗法。
Immunotherapies including adaptive immune checkpoint inhibitors (ICIs) and chimeric antigen receptor (CAR) T cells, have developed the treatment of cancer in clinic, and most of them focus on activating T cell immunity. Although these strategies have obtained unprecedented clinical responses, only limited subsets of cancer patients could receive long-term benefits, highlighting the demand for identifying novel targets for the new era of tumor immunotherapy. Innate immunity has been demonstrated to play a determinative role in the tumor microenvironment (TME) and influence the clinical outcomes of tumor patients. A thorough comprehension of the innate immune cells that infiltrate tumors would allow for the development of new therapeutics. In this review, we outline the role and mechanism of innate immunity in TME. Moreover, we discuss innate immunity-based cancer immunotherapy in basic and clinical studies. Finally, we summarize the challenges in sufficiently motivating innate immune responses and the corresponding strategies and measures to improve anti-tumor efficacy. This review could aid the comprehension of innate immunity and inspire the creation of brand-new immunotherapies for the treatment of cancer.
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影响因子：
30.5
作者：
Chiba, Shigeki;Baghdadi, Muhammad;Akiba, Hisaya;Yoshiyama, Hironori;Kinoshita, Ichiro;Dosaka-Akita, Hirotoshi;Fujioka, Yoichiro;Ohba, Yusuke;Gorman, Jacob V.;Colgan, John D.;Hirashima, Mitsuomi;Uede, Toshimitsu;Takaoka, Akinori;Yagita, Hideo;Jinushi, Masahisa
通讯作者：
Jinushi, Masahisa
影响因子：
10.9
作者：
De Sanctis F;Lamolinara A;Boschi F;Musiu C;Caligola S;Trovato R;Fiore A;Frusteri C;Anselmi C;Poffe O;Cestari T;Canè S;Sartoris S;Giugno R;Del Rosario G;Zappacosta B;Del Pizzo F;Fassan M;Dugnani E;Piemonti L;Bottani E;Decimo I;Paiella S;Salvia R;Lawlor RT;Corbo V;Park Y;Tuveson DA;Bassi C;Scarpa A;Iezzi M;Ugel S;Bronte V
通讯作者：
Bronte V
影响因子：
8
作者：
Chan, I. H.;Jain, R.;LaFace, D.
通讯作者：
LaFace, D.
影响因子：
3.7
作者：
Azab, Basem;Bhatt, Vijaya R.;Widmann, Warren D.
通讯作者：
Widmann, Warren D.
影响因子：
5.2
作者：
Cueto FJ;Sancho D
通讯作者：
Sancho D