General principles of medical therapy of inflammatory bowel disease
General principles of medical therapy of inflammatory bowel disease
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DOI：
10.1016/j.gtc.2004.02.003
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发表时间：
2004-06-01
影响因子：
3.7
通讯作者：
Friedman, S
中科院分区：
文献类型：
--
作者：
Friedman, S
溃疡性结肠炎（UC）和克罗恩病（CD）是影响患者生命黄金期的慢性胃肠道疾病。大多数患者从诊断到死亡都需要每天服用药物。由于炎症性肠病（IBD）患者通常具有正常的寿命，因此IBD的慢性药物治疗必须是可耐受的，易于坚持，并且副作用尽可能少。不同的患者需要不同类型的药物治疗，医生的治疗目标应反映其患者的治疗目标。本文讨论了IBD对生活质量的影响，并强调了适当和个性化药物治疗的重要性。为了帮助临床医生确定特定11313药物的疗效，本文对临床试验中使用的临床、内镜和生活质量终点进行了简要、实用的解释。最后，它提供了目前接受的UC和CD药物治疗的总结，以及在临床实践中使用这些药物的建议。
Ulcerative colitis (UC) and Crohn's disease (CD) are chronic gastrointestinal diseases that affect patients in the prime of their lives. Most patients need to take daily medications from diagnosis until death. Because inflammatory bowel disease (IBD) patients generally have a normal lifespan, chronic medical therapy for IBD must be tolerable, simple to adhere to, and have as few side effects as possible. Different patients require different types of medical therapy and treatment goals of physicians should reflect those of their patients. This article discusses the impact of IBD on quality of life and stresses the importance of appropriate and individualized medical therapy. To help clinicians determine the efficacy of particular 11313 medications, this article offers a brief, practical interpretation of clinical, endoscopic, and quality-of-life end points used in clinical trials. Finally, it provides a summary of the current accepted medical therapies for UC and CD and recommendations for using these medications in clinical practice.