Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study
Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study
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DOI：
10.1007/s00125-004-1637-7
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发表时间：
2005-02-01
期刊：
影响因子：
8.2
通讯作者：
Seidell, JC
中科院分区：
文献类型：
--
作者：
Snijder, MB;Visser, M;Seidell, JC
目的：我们调查了低皮下大腿脂肪是否是不利的葡萄糖和脂质水平的独立危险因素，以及这些关联是否在性别之间、白人和黑人之间存在差异。我们的第二个目的是研究人体测量测量（腰围和大腿围）反映了哪些身体组成特征（瘦组织和脂肪组织）。方法：对健康、衰老和身体组成研究的所有参与者进行了人体测量和腹部和大腿的计算机断层扫描，他们年龄在70 - 79岁之间。测定空腹血糖、甘油三酯和高密度脂蛋白胆固醇，以及负荷后2小时血糖。结果：在排除已经诊断为糖尿病或血脂异常的患者后，我们分析了来自2106名参与者的数据。在调整腹部皮下脂肪和内脏脂肪以及大腿肌间脂肪后，较大的大腿皮下脂肪面积与较低的ln-转化甘油三酯[标准化β (95% CI) - 0.12（- 0.20至- 0.04）男性和- 0.13（- 0.21至- 0.05）女性]和较高的ln- HDL-胆固醇[0.10（0.02至0.19）和0.09（0.01至0.18）分别相关。与较低血糖水平的相关性在男性中很强[空腹- 0.11(- 0.20至- 0.02)，负荷后血糖- 0.14(- 0.23至- 0.05)]，但在女性中无统计学意义[分别为- 0.02（- 0.10至0.07）和- 0.04(- 0.13至0.05)]。白人和黑人之间的联想没有差异。腰围与腹部皮下脂肪的相关性更强，这种相关性随着BMI的增加而增强，而与内脏脂肪的相关性则减弱。男性的大腿围同样取决于大腿脂肪和大腿肌肉，而女性的大腿围主要取决于脂肪成分。结论：考虑到腹部脂肪库与不利的葡萄糖和脂质水平相关后，较大的皮下大腿脂肪与更有利的葡萄糖（男性）和脂质水平（两性）独立相关。人体测量指标反映了腹部不同BMI水平的不同脂肪储存，并反映了大腿的脂肪和瘦肉组织。这些结果强调了在调查潜在健康风险时准确测量区域身体成分的重要性。
Aims: We investigated whether low subcutaneous thigh fat is an independent risk factor for unfavourable glucose and lipid levels, and whether these associations differ between sexes, and between white and black adults. Our secondary aim was to investigate which body composition characteristics ( lean tissue, fat tissue) are reflected by anthropometric measures ( waist and thigh circumference). Methods: Anthropometric measurements and computed tomography of the abdomen and of the thigh were performed for all participants of the Health, Aging and Body Composition Study, who were aged 70 - 79 years. Fasting glucose, triglycerides and HDL-cholesterol, and 2- h postload glucose were determined. Results: After excluding those already diagnosed with diabetes or dyslipidaemia, we analysed data from 2,106 participants. After adjustment for abdominal subcutaneous and visceral fat, and intermuscular thigh fat, larger thigh subcutaneous fat area was statistically significantly associated with lower ln- transformed triglycerides [ standardised beta ( 95% CI) - 0.12 (- 0.20 to - 0.04) in men and - 0.13 (- 0.21 to - 0.05) in women] and higher ln- HDL- cholesterol [ 0.10 ( 0.02 to 0.19) and 0.09 ( 0.01 to 0.18), respectively]. The associations with lower glucose levels were strong in men [- 0.11 (- 0.20 to - 0.02) for fasting and - 0.14 (- 0.23 to - 0.05) for postload glucose], but not statistically significant in women [- 0.02 (- 0.10 to 0.07) and - 0.04 (- 0.13 to 0.05), respectively]. There were no differences in the associations between white and black persons. Waist circumference was more strongly associated with abdominal subcutaneous fat, and this association became stronger with increasing BMI, whereas the association with visceral fat became weaker. Thigh circumference was equally dependent on thigh fat and thigh muscle in men, whereas in women the fat component was the main contributor. Conclusion: Larger subcutaneous thigh fat is independently associated with more favourable glucose ( in men) and lipid levels ( in both sexes) after accounting for abdominal fat depots, which are associated with unfavourable glucose and lipid levels. Anthropometric measures reflect different fat depots at different levels of BMI at the abdomen, and reflect both fat and lean tissue at the thigh. These results emphasise the importance of accurate measures of regional body composition when investigating potential health risks.