Pubertal Status and Age are Differentially Associated with Inflammatory Biomarkers in Female and Male Adolescents.
Pubertal Status and Age are Differentially Associated with Inflammatory Biomarkers in Female and Male Adolescents.
复制标题
青春期状态和年龄与女性和男性青少年的炎症生物标志物存在不同的相关性。
DOI：
10.1007/s10964-019-01101-3
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发表时间：
2020
影响因子：
4.9
通讯作者：
Alloy,LaurenB
中科院分区：
文献类型：
--
作者：
Stumper,Allison;Moriarity,DanielP;Coe,ChristopherL;Ellman,LaurenM;Abramson,LynY;Alloy,LaurenB
需要更好地了解青春期炎症活动的成熟相关性，以便更适当地研究正常和异常发育。炎症是免疫系统对感染、伤害或心理压力的第一反应，并且已被证明在患有身体和心理疾病的个体中炎症会升高。本研究在美国东北部城市的 155 名青少年（54.2% 女性，45.8% 男性；Mage= 16.22）的不同样本中检验了 (1) 青春期状态和炎症生物标志物，以及 (2) 年龄和炎症生物标志物之间的独特关联，以及这些关系是否因性别而异。青春期状态越晚，肿瘤坏死因子 α (TNF-α) 和白细胞介素 8 (IL-8) 水平越低。实际年龄与较低的 IL-8 水平有着独特的相关性。青春期状态与 C 反应蛋白 (CRP) 水平之间的关联因性别而异：更成熟的女性具有更高的 CRP，而男性的青春期状态和 CRP 没有显着相关性。这些发现强调了青春期发育与青春期炎症活动之间的重要关系。
A better understanding of the maturational correlates of inflammatory activity during adolescence is needed to more appropriately study both normal and abnormal development. Inflammation is the immune system’s first response to infection, injury, or psychological stress, and it has been shown to be elevated in individuals with both physical and psychological conditions. This study examined unique associations between (1) pubertal status and inflammatory biomarkers, and (2) age and inflammatory biomarkers, and whether these relationships differed by sex in a diverse sample of 155 adolescents (54.2% female, 45.8% male;Mage= 16.22) from a northeastern city in the US. A more advanced pubertal status was uniquely associated with lower levels of tumor necrosis factor alpha (TNF-α) and interleukin-8 (IL-8). Chronological age was uniquely associated with lower IL-8 levels. The association between pubertal status and C-reactive protein (CRP) levels differed by sex: more mature females had higher CRP, whereas pubertal status and CRP were not significantly associated in males. These findings highlight an important relation between pubertal development and inflammatory activity during adolescence.