Effector T cell plasticity: flexibility in the face of changing circumstances.
Effector T cell plasticity: flexibility in the face of changing circumstances.
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随着CD4 T细胞分化的其他状态被发现，它们的灵活性也开始被认识到。控制CD4 T细胞群体可塑性的组分包括其细胞条件、克隆性、转录电路和染色质修饰。细胞灵活性的出现可能来自真正灵活的遗传程序或异质群体。需要新的工具来定义允许或禁止细胞转换的规则。
As additional states of CD4 T cell differentiation are uncovered, their flexibility is also beginning to be recognized. Components that control the plasticity of CD4 T cell populations include their cellular conditions, clonality, transcriptional circuitry and chromatin modifications. Appearance of cellular flexibility may arise from truly flexible genetic programs or alternately heterogeneous populations. New tools will be needed to define the rules that allow or prohibit cellular transitions.