Immunocompetence and duration of immunity against Vibrio salmonicida and Aeromonas salmonicida after vaccination of Atlantic salmon (Salmo salar L) at low and high temperatures
Immunocompetence and duration of immunity against Vibrio salmonicida and Aeromonas salmonicida after vaccination of Atlantic salmon (Salmo salar L) at low and high temperatures
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DOI：
10.1006/fsim.1997.0080
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发表时间：
1997-05-01
影响因子：
4.7
通讯作者：
Killie, JEA
中科院分区：
文献类型：
--
作者：
Eggset, G;Mikkelsen, H;Killie, JEA
研究了环境温度对大西洋鲑免疫力和免疫持续时间的影响。免疫和抗体反应的鱼驯化和饲养在2和10摄氏度进行了检查后9，18和27周接种水和油乳化疫苗。所获得的结果表明，无论是水和油乳化疫苗对杀鲑弧菌的饲养温度无关的充分保护。接种预防风疹的疫苗证实了这一结果。然而，低温（2 ℃）延迟或强烈抑制了抗体反应。这些结果表明，免疫力可以完全建立在温度下显示是不允许的特异性抗体反应在大西洋鲑鱼。免疫持续时间似乎与温度和疫苗配方密切相关。在10摄氏度下饲养的鱼接种疫苗后18周，用疫苗获得的保护严重降低。高饲养温度对保护持续时间的这种负面影响通过疫苗抗原的油乳化而被完全防止。然而，高温对抗体产生的持续时间没有类似的影响。这可能表明抗体产生和免疫的持续时间不是由相同的机制维持的。(C)出版社：Academic Press Limited。
The influence of the environmental temperature or, immunocompetence and duration of immunity in Atlantic salmon was investigated. Immunity and antibody responses in fish acclimated and reared at 2 and 10 degrees C were examined 9, 18 and 27 weeks after vaccination with aqueous and oil-emulsified vaccines. The results obtained show that both aqueous and oil-emulsified vaccines gave full protection against Vibrio salmonicida independent of the rearing temperature. Vaccination against furunculosis served to confirm this result. However, the antibody response was delayed or strongly suppressed by low temperature (2 degrees C). These results show that immunity can be fully established at temperatures shown to be non-permissible for specific antibody responses in Atlantic salmon. Duration of immunity appears to be strongly correlated to temperature and vaccine formulation. Protection obtained with the acueous vaccine was severely reduced by 18 weeks after vaccination in fish reared at 10 degrees C. This negative effect of high rearing temperature on the duration of protection was fully prevented by the oil emulsification of the vaccine antigens. However, high temperature had no similar effect on the duration of antibody production. This may indicate that duration of antibody production and immunity is not maintained by the same mechanisms. (C) 1997 Academic Press Limited.