Ictal central apnea as a predictor for sudden unexpected death in epilepsy
Ictal central apnea as a predictor for sudden unexpected death in epilepsy
复制标题
DOI：
10.1016/j.yebeh.2011.06.036
复制
发表时间：
2011-10-01
影响因子：
2.6
通讯作者：
Gerard, Elizabeth E.
中科院分区：
文献类型：
--
作者：
Schuele, Stephan U.;Afshari, Mitra;Gerard, Elizabeth E.
缺乏流行病学证据表明局灶性癫痫发作期间的发作性低通气量与随后癫痫猝死(SUDEP)的高风险相关。我们描述一位颞叶癫痫患者，癫痫监测单元记录的两次局灶性癫痫发作持续57秒和58秒，与中枢性呼吸暂停有关。在这些活动中，她展示了氧气降至68%和62%的效果。患者随后在家中死于尸检确认的SUDEP。她房间里的听觉警报系统没有提醒这家人有任何癫痫发作活动，也没有睡在隔壁开着门的房间里。本病例强调癫痫发作时可出现发作性缺氧和SUDEP，但无明显的抽搐活动。该报告为越来越多的文献提供了可信度，这些文献表明，影响自主神经系统的癫痫可能倾向于SUDEP，而不依赖于继发性全身性惊厥的影响。(C)2011 Elsevier Inc.保留所有权利。
Epidemiological evidence associating ictal hypoventilation during focal seizures with a heightened risk for subsequent sudden unexpected death in epilepsy (SUDEP) is lacking. We describe a patient with temporal lobe epilepsy with two focal seizures recorded in the epilepsy monitoring unit that were associated with central apnea lasting 57 and 58 seconds. During these events, she demonstrated oxygen desaturation down to 68 and 62%. The patient subsequently died at home from autopsy-confirmed SUDEP. The family was not alerted of any seizure activity by the auditory alarm system in her room nor by sleeping in the adjacent room with open doors. This case emphasizes the fact that ictal hypoxia and SUDEP may occur in seizures without noticeable convulsive activity. The report gives credibility to the growing body of literature suggesting that epilepsies affecting the autonomic nervous system may predispose to SUDEP independent of the effects of a secondary generalized convulsion. (C) 2011 Elsevier Inc. All rights reserved.