SOLID-PHASE SYNTHESIS OF OLIGODEOXYNUCLEOTIDES CONTAINING PHOSPHORAMIDATE INTERNUCLEOTIDE LINKAGES AND THEIR SPECIFIC CHEMICAL CLEAVAGE
SOLID-PHASE SYNTHESIS OF OLIGODEOXYNUCLEOTIDES CONTAINING PHOSPHORAMIDATE INTERNUCLEOTIDE LINKAGES AND THEIR SPECIFIC CHEMICAL CLEAVAGE
复制标题
DOI：
10.1002/hlca.19880710618
复制
发表时间：
1988-01-01
影响因子：
1.8
通讯作者：
BANNWARTH, W
中科院分区：
文献类型：
--
作者：
BANNWARTH, W
带有氨基磷酸酯核苷酸间键的寡核苷酸可以通过标准固相DNA合成化学制备。因此，氨基磷酸酯核苷酸间键可以随意置于给定DNA片段内的特定位置。以这种方式制备的主链修饰的DNA片段对特异性化学切割敏感。
Oligonucleotides bearing phosphoramidate internucleotide linkages can be prepared chemically by standared solid-phase DNA synthesis. Thus, phosphoramidate internucleotide bonds can be placed at will into specific positions within a given DNA fragment. The backbone-modified DNA fragments prepared in this way are susceptible to a specific chemical cleavage.