Neural Activity in Primate Caudate Nucleus Associated With Pro- and Antisaccades
Neural Activity in Primate Caudate Nucleus Associated With Pro- and Antisaccades
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DOI：
10.1152/jn.00125.2009
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发表时间：
2009-10-01
影响因子：
2.5
通讯作者：
Everling, Stefan
中科院分区：
文献类型：
--
作者：
Ford, Kristen A.;Everling, Stefan
福特KA，埃弗林S.灵长类动物尾状核的神经活动与正反跳有关。J Neurophysiol 102：2334-2341，2009.首次发表于2009年8月19日; doi：10.1152/jn.00125.2009。基底神经节（BG）在运动中起着核心作用，并且已经证明，这些结构中的神经元的放电速率受到给定任务的行为背景的调制。在这里，我们使用的antisaccade任务，其中一个扫视对一个闪烁的视觉刺激必须被抑制，有利于扫视到相反的位置，调查的尾状核，BG的主要输入结构的作用，在灵活的行为。在这项研究中，我们记录了细胞外神经元的活动，而猴子进行的亲和反accade试验。我们确定了两个群体的神经元：那些喜欢对侧扫视（CSN）和那些喜欢同侧扫视（ISNs）。CSN增加了他们的射击率为prosaccade，但不为antisaccade，和ISN增加了他们的射击率为antisaccade，但不为prosaccade。我们提出了一个模型，其中CSN投射到直接BG通路，促进眼跳，而ISN投射到间接通路，抑制眼跳。这个模型提出了一种可能的机制，通过这种机制，这些神经元群体可以调节上级丘的活动。
Ford KA, Everling S. Neural activity in primate caudate nucleus associated with pro- and antisaccades. J Neurophysiol 102: 2334-2341, 2009. First published August 19, 2009; doi:10.1152/jn.00125.2009. The basal ganglia (BG) play a central role in movement and it has been demonstrated that the discharge rate of neurons in these structures are modulated by the behavioral context of a given task. Here we used the antisaccade task, in which a saccade toward a flashed visual stimulus must be inhibited in favor of a saccade to the opposite location, to investigate the role of the caudate nucleus, a major input structure of the BG, in flexible behavior. In this study, we recorded extracellular neuronal activity while monkeys performed pro- and antisaccade trials. We identified two populations of neurons: those that preferred contralateral saccades (CSNs) and those that preferred ipsilateral saccades (ISNs). CSNs increased their firing rates for prosaccades, but not for antisaccades, and ISNs increased their firing rates for antisaccades, but not for prosaccades. We propose a model in which CSNs project to the direct BG pathway, facilitating saccades, and ISNs project to the indirect pathway, suppressing saccades. This model suggests one possible mechanism by which these neuronal populations could be modulating activity in the superior colliculus.