Does substance P coexist with adrenaline in neurones of the rostral ventrolateral medulla in the rat?
Does substance P coexist with adrenaline in neurones of the rostral ventrolateral medulla in the rat?
复制标题
P物质是否与大鼠延髓头侧腹外侧神经元中的肾上腺素共存？
DOI：
10.1016/0304-3940(86)90636-1
复制
发表时间：
1986
影响因子：
2.5
通讯作者：
J. Chalmers
中科院分区：
文献类型：
--
作者：
P. Pilowsky;J. Minson;A. Hodgson;P. Howe;J. Chalmers
脊髓投射的P物质（SP）和含肾上腺素的神经元的头端腹外侧延髓被认为是重要的紧张性和反射控制的血压。在本文中，我们使用双重免疫荧光染色，以调查这两个假定的神经递质在这一地区的共定位的程度。与最近的一份报告，SP和苯乙醇胺-N-甲基转移酶（PNMT）是广泛的共定位，我们在这里报告，只有少数的神经元被发现是SP和PNMT的免疫反应。
Spinally projecting substance P- (SP) and adrenaline-containing neurones of the rostral ventrolateral medulla are believed to be important in the tonic and reflex control of blood pressure. In this paper we used dual immunofluorescence staining to investigate the degree of co-localisation of these two putative neurotransmitters in this region. In contrast to a recent report that SP and phenylethanolamine-N-methyl-transferase (PNMT) are extensively co-localised, we report here that only a small number of neurones were found to be immunoreactive for both SP and PNMT.