Sweet taste-induced analgesia: an fMRI study
Sweet taste-induced analgesia: an fMRI study
复制标题
DOI：
10.1097/wnr.0b013e3283383df5
复制
发表时间：
2010-04-21
期刊：
影响因子：
1.7
通讯作者：
Saito, Shigeru
中科院分区：
文献类型：
--
作者：
Kakeda, Takahiro;Ogino, Yuichi;Saito, Shigeru
我们用3-T功能磁共振成像研究了与甜味镇痛相关的脑激活，其机制被认为涉及中枢神经系统。12名健康受试者在磁共振成像扫描机架上摄入无味明胶(非甜味状态)或甜味葡萄糖(甜味状态)后，对他们的前臂内侧进行冷加压试验。在这两种条件下，冷加压测试都有力地激活了疼痛相关的神经网络，特别是前扣带皮质、脑岛、顶叶后皮质和丘脑，尽管与非甜味条件相比，甜味条件下这种激活随着痛阈值的增加而减弱。结合疼痛评估中的情绪变化，我们的发现为人类大脑中甜味诱导的止痛提供了客观的表征。神经报告21：427-431(C)2010 Wolters Kluwer Health|Lippincott Williams&Wilkins。
We investigated the brain activation associated with sweet taste-induced analgesia by 3-T functional magnetic resonance imaging, the mechanism of which is considered to involve the central nervous system. After 12 healthy individuals ingested tasteless gelatin (nonsweet condition) or sweet glucose (sweet condition) in a magnetic resonance imaging scanning gantry, the cold pressor test was applied to their medial forearm. Under both conditions, the cold pressor test robustly activated the pain-related neural network, notably the anterior cingulate cortex, insula, posterior parietal cortex, and thalamus, although such activations under the sweet condition weakened with pain threshold increase, compared with those under the nonsweet condition. Together with emotional changes in pain appraisal, our findings provide objective representation of sweet taste-induced analgesia in the human brain. NeuroReport 21: 427-431 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.