VALIDATION AND APPLICATION OF DUAL-ENERGY X-RAY ABSORPTIOMETRY TO MEASURE BONE MASS AND BODY-COMPOSITION IN SMALL INFANTS
VALIDATION AND APPLICATION OF DUAL-ENERGY X-RAY ABSORPTIOMETRY TO MEASURE BONE MASS AND BODY-COMPOSITION IN SMALL INFANTS
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DOI：
10.1093/ajcn/58.6.839
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发表时间：
1993-12-01
影响因子：
7.1
通讯作者：
ATKINSON, SA
中科院分区：
文献类型：
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作者：
BRUNTON, JA;BAYLEY, HS;ATKINSON, SA
通过1)扫描三份仔猪以计算变异系数，以及2)将DXA估计值与整个身体的化学分析进行比较，评估了双能X射线吸收测量仪(DXA)分析婴儿全身成分的精确度和有效性。除脂肪量分别为6.3%和3.5%外，小型仔猪和大型仔猪所有DXA指标的平均变异系数均为-2.5%。在大型仔猪中，DXA为骨矿含量(BMC)、瘦体质量和脂肪质量提供了合理的化学分析估计，但仅对小型仔猪的瘦体质量提供了合理的估计。DXA将小猪的脂肪高估了两倍，将BMC低估了三分之一。对17名早产儿在足月、3、6和12个月校正年龄的扫描显示，BMC、瘦体重和脂肪质量的变化可以用DXA来定量。然而，在获得可靠的小婴儿BMC和脂肪量测量之前，DXA技术的进一步完善是必要的。
Precision and validity of dual-energy x-ray absorptiometry (DXA) for analysis of whole-body composition in infants were assessed by 1) scanning piglets in triplicate to calculate CVs, and 2) comparing DXA estimates with chemical analysis of whole carcass. The mean CVs for all DXA measures in small piglets and large piglets were < 2.5%, except for fat mass, which were 6.3% and 3.5%, respectively. In large piglets DXA provided reasonable estimates of chemical analysis for bone mineral content (BMC), lean body mass, and fat mass, but only for lean body mass in small piglets. DXA overestimated fat by twofold and underestimated BMC by a third in small piglets. Scans of prematurely born infants (n = 17) at term and at 3, 6, and 12 mo corrected age demonstrated that changes in BMC, lean body mass, and fat mass can be quantitated by DXA. However, further refinement of DXA technology is necessary before reliable measures of BMC and fat mass in small infants are attainable.