Amygdaloid Kindling and the GABA System
Amygdaloid Kindling and the GABA System
复制标题
杏仁核点燃和 GABA 系统
DOI：
10.1111/j.1528-1157.1980.tb04058.x
复制
发表时间：
1980
期刊：
影响因子：
5.6
通讯作者：
E. Valenstein
中科院分区：
文献类型：
--
作者：
M. Myslobodsky;E. Valenstein
总结：在Long-Evans大鼠中研究了脑GABA水平升高对杏仁核完全点燃癫痫发作的影响。将新合成的GABA-转氨酶抑制剂-γ-炔属GABA（GAG）连续四天（100 mg/kg，随后50 mg/kg，i. p.）被发现可以显著减少或完全消除通常由杏仁核刺激产生的行为癫痫发作。在第一次注射GAG后观察到该效应，尽管其幅度在随后几天更大。GAG给药终止后2 - 3天，行为性癫痫发作再次出现。在GAG治疗的第一天，电描记癫痫发作（放电后杏仁核自我维持）的持续时间保持不变或更长，但在随后的几天更短。后放电持续时间比行为性癫痫发作早1 ~ 2天恢复正常。印防己毒素（1.5 - 2 mg/kg，i. p.）没有拮抗电图或行为的抑制与GAG产生的影响。在印防己毒素诱导的初始镇静阶段对杏仁核进行电刺激，导致大多数动物的点燃癫痫发作进一步消退。尽管在使用的剂量下，GAG可使杏仁核点燃的癫痫发作加重，但鉴于其降低唤醒水平的能力，需要谨慎使用。
Summary: The effect of increased brain GABA levels on fully kindled amygdala seizures was investigated in Long‐Evans rats. The newly synthesized GABA‐transaminase inhibitor, ‐γ‐acetylenic GABA (GAG) administered on four consecutive days (100 mg/kg, followed by 50 mg/kg, i.p.) was found to either significantly reduce, or eliminate entirely, the behavioral seizures normally produced by amygdala stimulation. The effect is seen after the first injection of GAG although its magnitude was greater on subsequent days. Behavioral seizures reappeared 2 to 3 days after termination of GAG treatment. The duration of electrographic seizures (self‐sustained amygdala after‐discharge) was either unchanged or greater on the first day of GAG treatment, but was briefer on subsequent days. The duration of afterdischarges returned to normal levels 1 to 2 days earlier than the behavioral seizures after the termination of GAG. Picrotoxin (1.5‐2 mg/kg, i.p.) did not antagonize either electrographic or behavioral effects of inhibition produced with GAG. Electrical stimulation of amygdala delivered during the initial sedation stage induced by picrotoxin resulted in further regression of kindled seizures in the majority of animals. Although in doses employed, GAG alleviates amygdaloid‐kindled seizures its use requires caution in view of its ability to reduce arousal level.