Glioblastoma: Defining Tumor Niches.
Glioblastoma: Defining Tumor Niches.
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DOI：
10.1016/j.trecan.2015.10.009
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发表时间：
2015-12
期刊：
影响因子：
18.4
通讯作者：
Bergers G
中科院分区：
文献类型：
--
作者：
Hambardzumyan D;Bergers G
胶质母细胞瘤（GBM）是最难治疗的脑肿瘤之一，因为它们具有侵袭性生长和对治疗的抗性。它们在分子和组织学水平上都是高度异质性的恶性肿瘤。特异性的组织学标志包括假性扁平化坏死和微血管增生将GBM与低级别胶质瘤区分开来，并使GBM成为最缺氧和血管生成的肿瘤之一。这些微解剖区室在肿瘤微环境中呈现特定的小生境，调节代谢需求、免疫监视、存活、侵袭以及癌症干细胞维持。在这里，我们审查的特点和功能的不同GBM龛，详细介绍了不同的细胞成分和功能状态的脉管系统，并讨论了治疗靶向GBM龛成分的前景。
Glioblastomas (GBM) are one of the most recalcitrant brain tumors because of their aggressive invasive growth and resistance to therapy. They are highly heterogeneous malignancies at both the molecular and histological levels. Specific histological hallmarks including pseudopalisading necrosis and microvascular proliferation distinguish GBM from lower-grade gliomas, and make GBM one of the most hypoxic as well as angiogenic tumors. These microanatomical compartments present specific niches within the tumor microenvironment that regulate metabolic needs, immune surveillance, survival, invasion as well as cancer stem cell maintenance. Here we review features and functions of the distinct GBM niches, detail the different cell constituents and the functional status of the vasculature, and discuss prospects of therapeutically targeting GBM niche constituents.