Systematic, balancing gradients in neuron density and number across the primate isocortex.
Systematic, balancing gradients in neuron density and number across the primate isocortex.
复制标题
灵长类同皮质神经元密度和数量的系统性平衡梯度。
DOI：
10.3389/fnana.2012.00028
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发表时间：
2012
影响因子：
2.9
通讯作者：
Finlay BL
中科院分区：
文献类型：
--
作者：
Cahalane DJ;Charvet CJ;Finlay BL
大脑皮层的细胞和区域组织影响它处理和整合信息的方式。一个多世纪以来，人们一直在争论这个组织是如何出现的，以及如何最好地描述它。在这里，我们展示并描述了在七种灵长类动物的等皮质中，神经元密度和单位面积下神经元数量的明显从前到后的梯度。我们的发现表明，灵长类等皮质的细胞结构既不是均匀排列的，也不是以任意空间排列的离散斑块。相反，它表现出惊人的系统性变化。我们推测，这些梯度建立了建立更丰富的区域和细胞结构所基于的基本景观，是不同物种之间保存的皮质神经发生发育模式的结果。此外，我们提出了一个功能结果：单位皮质区域神经元的梯度促进了信息沿感觉区域上升并向额叶皮质上升的整合和降维。
The cellular and areal organization of the cerebral cortex impacts how it processes and integrates information. How that organization emerges and how best to characterize it has been debated for over a century. Here we demonstrate and describe in the isocortices of seven primate species a pronounced anterior-to-posterior gradient in the density of neurons and in the number of neurons under a unit area of the cortical surface. Our findings assert that the cellular architecture of the primate isocortex is neither arranged uniformly nor into discrete patches with an arbitrary spatial arrangement. Rather, it exhibits striking systematic variation. We conjecture that these gradients, which establish the basic landscape that richer areal and cellular structure is built upon, result from developmental patterns of cortical neurogenesis which are conserved across species. Moreover, we propose a functional consequence: that the gradient in neurons per unit of cortical area fosters the integration and dimensional reduction of information along its ascent through sensory areas and toward frontal cortex.