Meta-analysis of outcomes of patients with COVID-19 infection with versus without gastrointestinal symptoms.
Meta-analysis of outcomes of patients with COVID-19 infection with versus without gastrointestinal symptoms.
复制标题
DOI：
10.1080/08998280.2020.1771164
复制
发表时间：
2020-07-01
期刊：
影响因子：
--
通讯作者：
Rangaswami, Janani
中科院分区：
文献类型：
--
作者：
Gul, Fahad;Lo, Kevin Bryan;Rangaswami, Janani
这项系统评价分析了 SARS-COV-2 感染患者是否存在胃肠道症状是否与不良后果相关。我们检索了 Cochrane 中心对照试验注册库，纳入了所有针对有胃肠道症状（恶心、呕吐、腹泻、腹痛）的 COVID-19 患者与作为对照组但没有胃肠道症状的 COVID-19 患者进行比较的研究。最终检索出 186 篇文章，所有文章均经过单独筛选。确定了七项研究，但三项被排除：一项是由于缺乏没有胃肠道症状的对照组，一项报告为粪便中的病毒RNA，另一项仅针对非危重患者。荟萃分析结果显示，患有 COVID-19 和胃肠道症状的患者死亡率的汇总比值比为 0.91（置信区间 0.49-1.68），异质性为 0%；急性呼吸窘迫综合征的汇总比值比为 2.94（置信区间 1.17-7.40），异质性为 0%。总之，COVID-19 胃肠道症状与急性呼吸窘迫综合征的较高风险相关，但不会增加死亡风险。
This systematic review analyzed whether the presence or absence of gastrointestinal symptoms in patients with SARS-COV-2 infection is associated with adverse outcomes. Searching the Cochrane Center Register of Controlled Trials, we included any studies looking at patients with COVID-19 with gastrointestinal symptoms (nausea, vomiting, diarrhea, abdominal pain) compared to those with COVID-19 but without gastrointestinal manifestations as a control group. The final search yielded 186 articles, all of which were individually screened. Seven studies were identified but three were excluded: one due to lack of a control group without gastrointestinal symptoms, one reported as viral RNA in the stool, and one with only non-critically ill patients. Results of the meta-analysis showed a pooled odds ratio for mortality among those with COVID-19 and gastrointestinal symptoms of 0.91 (confidence interval 0.49-1.68) with heterogeneity of 0% and a pooled odds ratio for acute respiratory distress syndrome of 2.94 (confidence interval 1.17-7.40) with heterogeneity of 0%. In conclusion, gastrointestinal symptoms with COVID-19 are associated with a higher risk of acute respiratory distress syndrome, but do not increase the risk for mortality.