Consistent associations of HLA class I and II and transporter gene products with progression of human immunodeficiency virus type 1 infection in homosexual men
Consistent associations of HLA class I and II and transporter gene products with progression of human immunodeficiency virus type 1 infection in homosexual men
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DOI：
10.1086/314862
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发表时间：
1999-08-01
影响因子：
6.4
通讯作者：
Kaslow, RA
中科院分区：
文献类型：
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作者：
Keet, IPM;Tang, J;Kaslow, RA
在人类免疫缺陷病毒1型（HIV-1）感染的过程中的HLA区域的基因多态性产物的变异性进行了鉴定，通过筛选375高加索人血清转换谁聚集从3个队列。无艾滋病的时间与许多（15）I类等位基因，单独或与转运蛋白变异体，在A或B基因座的纯合性，和两个II类单倍型的等位基因。从3个队列中获得的预后评分算法捕获了多个HLA对保护或风险的贡献（相对危险度= 0.57-60/评分单位增加，所有P
Polymorphic products of genes in the HLA region contributing to variability in the course of human immunodeficiency virus type 1 (HIV-1) infection were identified by screening 375 Caucasian seroconverters who were aggregated from 3 cohorts. AIDS-free time was related to numerous (15) class I alleles, alone or in conjunction with transporter protein variants, to homozygosity at the A or B locus, and to alleles of two class II haplotypes. A prognostic scoring algorithm derived from the 3 cohorts captured multiple HLA contributions to protection or to risk (relative hazard = 0.57-60 per unit increase in score, all P