Conceptual design of a proton computed tomography system for applications in proton radiation therapy
Conceptual design of a proton computed tomography system for applications in proton radiation therapy
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DOI：
10.1109/tns.2004.829392
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发表时间：
2004-06-01
影响因子：
1.8
通讯作者：
Woody, C
中科院分区：
文献类型：
--
作者：
Schulte, R;Bashkirov, V;Woody, C
质子计算机断层扫描（pCT）有可能提高质子治疗计划剂量计算的准确性，也将有助于患者相对于质子束定位的预处理验证。进行了一项设计研究，以根据质子治疗应用的规范定义pCT系统的最佳方法。提出了pCT系统的概念和详细设计;该系统由硅基粒子跟踪系统和晶体量热计组成，以测量单个质子的能量损失。我们讨论了形成的pCT图像的基础上重建的体积电子密度图和图像重建的分析和统计算法的适用性。
Proton computed tomography (pCT) has the potential to improve the accuracy of dose calculations for proton treatment planning, and will also be useful for pretreatment verification of patient positioning relative to the proton beam. A design study was performed to define the optimal approach to a pCT system based on specifications for applications in proton therapy. Conceptual and detailed design of a pCT system is presented; the system consists of a silicon-based particle tracking system and a crystal calorimeter to measure energy loss of individual protons. We discuss the formation of pCT images based on the reconstruction of volume electron density maps and the suitability of analytic and statistical algorithms for image reconstruction.