Cutting Edge: Pulmonary Legionella pneumophila Is Controlled by Plasmacytoid Dendritic Cells but Not Type I IFN
Cutting Edge: Pulmonary Legionella pneumophila Is Controlled by Plasmacytoid Dendritic Cells but Not Type I IFN
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DOI：
10.4049/jimmunol.1000128
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发表时间：
2010-05-15
影响因子：
4.4
通讯作者：
van Driel, Ian R.
中科院分区：
文献类型：
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作者：
Ang, Desmond K. Y.;Oates, Clare V. L.;van Driel, Ian R.
浆细胞样树突状细胞（pDCs）是众所周知的主要细胞类型分泌I型IFN响应病毒感染。它们在对抗其他种类的感染性生物（包括细菌）中的作用及其作用机制尚不清楚。我们发现，pDCs在细胞内细菌病原体嗜肺军团菌的急性反应中发挥重要作用。pDCs被迅速招募到嗜肺乳杆菌感染小鼠的肺部，pDCs的消耗导致细菌负荷增加。pDCs对抗感染的能力不需要I型干扰素。这项研究指出了pDCs在对抗细菌感染中的作用，并指出了这种细胞类型的一种新的作用机制。免疫学杂志，2010,18(4):529 - 533。
Plasmacytoid dendritic cells (pDCs) are well known as the major cell type that secretes type I IFN in response to viral infections. Their role in combating other classes of infectious organisms, including bacteria, and their mechanisms of action are poorly understood. We have found that pDCs play a significant role in the acute response to the intracellular bacterial pathogen Legionella pneumophila. pDCs were rapidly recruited to the lungs of L. pneumophila-infected mice, and depletion of pDCs resulted in increased bacterial load. The ability of pDCs to combat infection did not require type I IFN. This study points to an unappreciated role for pDCs in combating bacterial infections and indicates a novel mechanism of action for this cell type. The Journal of Immunology, 2010, 184: 5429-5433.