Enol Ester Synthesis via Cobalt-Catalyzed Regio- and Stereoselective Addition of Carboxylic Acids to Alkynes.
Enol Ester Synthesis via Cobalt-Catalyzed Regio- and Stereoselective Addition of Carboxylic Acids to Alkynes.
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DOI：
10.1021/acs.orglett.8b02824
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发表时间：
2018-10
期刊：
影响因子：
5.2
通讯作者：
Jia-Feng Chen;Changkun Li
中科院分区：
文献类型：
--
作者：
Jia-Feng Chen;Changkun Li
报道了一种钴催化的高区域和立体选择性的炔烃氢氧羰化反应。末端和内部的炔烃都可以与羧酸反应，以高产率得到烯醇酯。由Co(BF4)2、三齿膦配体L5和原位锌生成的催化剂比相应的钴/双膦络合物具有更高的反应活性。
A cobalt-catalyzed highly regio- and stereoselective hydro-oxycarbonylation of alkynes is reported. Both terminal and internal alkynes can react with carboxylic acids to afford enol esters in high yields. The catalyst generated from Co(BF4)2, tridentate phosphine ligand L5, and zinc in situ exhibits much higher reactivity than the corresponding cobalt/diphosphine complex.