Association of a promoter polymorphism of the CD14 gene and atopy
Association of a promoter polymorphism of the CD14 gene and atopy
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DOI：
10.1164/ajrccm.163.4.2004164
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发表时间：
2001-03-01
影响因子：
24.7
通讯作者：
Bleecker, ER
中科院分区：
文献类型：
--
作者：
Koppelman, GH;Reijmerink, NE;Bleecker, ER
特应性通常被认为是由遗传和环境因素相互作用引起的。最近，美国一项针对学童的人口研究报告了染色体 5q31.1 上 CD14 基因启动子区域的 C 到 T 转变与特应性表型之间的关联。本研究的目的是调查 CD14/-159 的 C 等位基因与荷兰成年人群特应性和哮喘表型的关联，其中总血清 IgE 和支气管高反应性与染色体 5q31-33 存在关联。我们研究了 159 名哮喘先证者和 158 名配偶作为对照。研究了哮喘表型（例如支气管高反应性、医生诊断）和特应性表型（例如血清总 IgE 水平、皮内皮试、过敏性鼻炎）。在该人群中，与具有 CT 和 TT 等位基因的受试者相比，C 等位基因纯合子的皮试阳性次数较多，血清总 IgE 水平较高（皮试阳性个体），随后，自我报告的过敏症状（包括鼻炎和花粉热）较多。我们得出结论，CD14 基因中的 -159 C-to-T 启动子多态性可能导致表达更严重的过敏表型。
Atopy is generally considered to be caused by interaction of genetic and environmental factors. Recently, an association of a C-to-T transition in the promoter region of the CD14 gene on chromosome 5q31.1 and atopic phenotypes was reported in a population study of school children in the United States. The aim of the present study was to investigate the association of the C allele of the CD14/-159 with phenotypes of atopy and asthma in an adult Dutch population in which linkage of total serum IgE and bronchial hyperresponsiveness to chromosome 5q31-33 is present. We studied 159 probands with asthma and 158 spouses as controls. Phenotypes for asthma (e,g., bronchial hyperresponsiveness, physician's diagnosis) and for atopy (e.g., total serum IgE level, intracutaneous skin test, allergic rhinitis) were studied. In this population, homozygotes for the C allele had a higher number of positive skin tests and higher total serum IgE levels tin skin test-positive individuals) and subsequently, more self-reported allergic symptoms including rhinitis and hay fever, compared with subjects with CT and TT alleles, We conclude that the -159 C-to-T promoter polymorphism in the CD14 gene may result in expression of a more severe allergic phenotype.